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  • Gluten Free Gluten Free
  • Non-GMO Non-GMO

AOR SAMe, 400mg

AOR SAMe, 400mg

  • Vendor:by AOR
  • 5.0
    Rated 5.0 out of 5 stars
    4 Reviews


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  • Vegan Vegan
  • Gluten Free Gluten Free
  • Non-GMO Non-GMO

AOR SAMe, 400mg

AOR SAMe, 400mg

:by AOR

Regular price $48.00 USD
Sale price $48.00 USD Regular price $47.00
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AOR SAMe 400 Details

SAMe 400 is s-adenosyl-L-methionine (SAMe), a key biological factor that drives a wide variety of essential biochemical reactions, including the methylation of DNA, catecholamine neurotransmitters (brain messenger molecules), phospholipids, hormones, and chondrocytes (cartilage-forming cells). Research suggests SAMe's ability to support healthy mood function to relieve symptoms and reduce functional impairment in osteoarthritis. SAMe 400 provides a full 400 mg of true SAMe ion per enterically coated tablet, with a minimum of 70% biologically active (S), S-diastereoisomer.

S-adenosyl-l-methionine (SAMe) is a natural compound and methyl group donor that supports the methylation cycle, a process that is essential for many aspects of health. Methylation is fundamental for ridding the body of certain toxins, and certain people, such as those with chronic liver disorders, cannot produce adequate levels of SAMe. 
SAMe’s effectiveness in supporting a balanced mood is demonstrated by many clinical studies. SAMe is so effective for boosting a low mood that it is legally registered as a prescription drug in several European countries for mood balance. It is thought that SAMe works by helping boost serotonin, dopamine, and melatonin levels in the brain, low levels of which are commonly associated with mood imbalances such as anxiety. SAMe has also been found to support joint health in osteoarthritis patients as effectively as a popular anti-inflammatory drug by reducing inflammation and protecting joint tissue from degradation. 
AOR introduced the first SAMe supplement to Canada in 2000. SAMe can provide mood support, benefit those suffering from osteoarthritis, and is essential for those with liver disorders to maintain good health. AOR’s SAMe 400 provides an effective dosage and a stable form of this valuable compound in an enteric-coated tablet for maximum effectiveness.

AOR SAMe, 400mg Features and Benefits

  • Supports mood regulation
  • Relieves symptoms of osteoarthritis
  • Supports normal liver function
  • Supports methylation


Take 2 or 3 AOR SAMe 400 tablets daily on an empty stomach, or as directed by a qualified health care practitioner. Use for a minimum of 4 weeks to see beneficial effects for osteoarthritic pain, and a minimum of 2 weeks for mood support.

Nutrition Facts / Valeur nutritive

Nutrition Facts
Serving Size: 1 Tablet
Servings per Container: 30
Amount Per Serving
SAMe Disulfate Tosylate 800 mg
Ionic SAMe 400 mg
* Percent daily values are based on a 2000 calorie diet
† Daily Value not established
Note: Serving Sizes are rounded to the nearest whole serving

Additional Ingredients

Silicon dioxide, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, ascorbic acid, citric acid (anhydrous), stearic acid, methacrylic acid co-polymer dispersion NF, triethyl citrate, titanium dioxide, riboflavin, mannitol.

AOR SAMe Customer Reviews

Rated 5.0 out of 5 stars
Based on 4 reviews
4 reviews
  • L
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    5 Stars

    I believe this works! I started 2 months ago for mood and focus. I wish it wasn’t so pricy but so far it’s been worth the cost which says a lot. I have already repurchased the bigger box.

  • CW
    Cindy W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago

    2 a day and within a only a few days alleviates ********** and anxiety noticeably. So much better than all the pharmaceutical drugs I have tried. Used in Europe a great deal but is by doctor prescription only .

  • SM
    I recommend this product
    Rated 5 out of 5 stars
    3 years ago

    Would not be without it.

  • MC
    Marni C.
    I recommend this product
    Rated 5 out of 5 stars
    6 years ago
    Great Product

    I take one pill every morning and 1 capsule of NEM every night and it virtually eliminated my arthritis aches and pains. On a scale of 1-10 my pain level is a 1.

    I will never be without this product. The usual arthritis supplements (glucosamine, MSM, chondroitin) do not work for me. This does. Product is a bit pricey though.

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