Xymogen HistDAO, Supports Healthy Histamine Digestion and Digestive Comfort, 60 Delayed Release Tablets

Xymogen HistDAO Details

Xymogen HistDAO provides DAO (diamine oxidase) — the natural enzyme your body uses to break down histamine from food in the digestive tract — in a delayed-release tablet. For people who are sensitive to histamine-rich foods, supplementing DAO before meals can support healthy histamine digestion and digestive comfort. The delayed-release tablet helps the DAO enzyme reach the small intestine, where dietary histamine is broken down. Xymogen is a US-based premium practitioner brand sold through healthcare professionals. For adults with histamine sensitivity seeking mealtime digestive support. 60 delayed-release tablets.

Vitamins Lowest Prices | Lowest Price in Canada — Guaranteed | Ships from Ontario across Canada

Quick Facts

Who Xymogen HistDAO Is For

• Adults sensitive to histamine-rich foods (aged cheese, wine, fermented foods, cured meats) seeking mealtime support
• People working with a practitioner on histamine sensitivity who want DAO enzyme support
• Adults who experience digestive discomfort after histamine-rich meals
• People wanting a practitioner-grade DAO supplement with delayed-release delivery
• Anyone exploring DAO support as part of a low-histamine dietary approach
• Adults wanting premium practitioner-tier histamine digestion support

Who this product is NOT for: If you suspect histamine intolerance or have ongoing symptoms, work with a healthcare practitioner — histamine sensitivity can overlap with other conditions, and proper assessment matters. DAO supplements support the digestion of food-derived histamine; they don't address histamine your body produces internally (such as in allergic reactions), so they are not a treatment for allergies. If you have a true food allergy, DAO is not a substitute for allergy management or emergency medication — consult your practitioner. If you take medications, are pregnant or breastfeeding, consult your practitioner. If you want a broader histamine-sensitivity supplement approach, browse our histamine and immune options.

Vitamart's Take

Xymogen HistDAO is a digestive-support supplement for people who are sensitive to histamine-rich foods such as aged cheese, wine, and fermented foods. It provides DAO, a natural enzyme the body uses to break down histamine from food, in delayed-release tablets designed to help the enzyme reach the gut intact.

How Xymogen HistDAO Compares

HistDAO vs Antihistamines

HistDAO (this product): An enzyme that breaks down histamine from food in the digestive tract — a digestive, food-focused approach.
Antihistamines: Medications that block histamine receptors in the body — a different mechanism for allergic responses. A fit for allergies, under medical guidance. Different purposes entirely.

HistDAO vs Low-Histamine Diet

HistDAO (this product): Supports digestion of dietary histamine, used before histamine-rich meals.
Low-Histamine Diet: Avoiding histamine-rich foods altogether. A fit as a foundational approach; many people combine a low-histamine diet with DAO for occasional higher-histamine meals.

HistDAO vs Digestive Enzymes

HistDAO (this product): Specifically provides DAO to break down histamine.
Digestive Enzymes: Break down protein, fat, and carbs — general digestion, not histamine-specific. A fit for general meal digestion. Different targets.

What Is DAO and Histamine Sensitivity?

Understanding the DAO-histamine connection helps explain how this works:

• Histamine in food: Histamine occurs naturally in many foods, especially aged, fermented, and cured ones — aged cheese, wine, sauerkraut, cured meats, and more. This is dietary histamine.
• DAO's job: Diamine oxidase (DAO) is an enzyme your gut produces to break down histamine from food before it's absorbed. It's your body's natural mealtime histamine processor.
• Lower DAO activity: Some people have reduced DAO activity, which means dietary histamine isn't broken down as efficiently. This can lead to sensitivity and digestive discomfort after histamine-rich foods.
• How supplementing helps: Taking DAO before a histamine-rich meal provides extra enzyme to help break down the histamine in that food, supporting digestive comfort.
• Food histamine only: Importantly, supplemental DAO works on histamine from food in the gut. It doesn't affect histamine your body produces internally (such as during allergic reactions) — so it's not an allergy treatment.
• Delayed-release matters: The enzyme needs to reach the small intestine intact. A delayed-release tablet protects the DAO through the stomach so it's active where dietary histamine is processed.

How To Use

Adults: Take 1 tablet about 15 minutes before a histamine-rich meal, or as directed by your healthcare practitioner. Because DAO works on food histamine, timing it before the meal is key — it provides the enzyme as the histamine-containing food arrives. Swallow the delayed-release tablet whole.

Talk to a healthcare practitioner before use if you have ongoing symptoms or suspect histamine intolerance (proper assessment matters), have a food allergy (DAO is not a substitute for allergy management or emergency medication), take medications, or are pregnant or breastfeeding. DAO supports food-histamine digestion and is not a treatment for allergies or medical conditions.

Frequently Asked Questions

Pairs Well With

• Digestive Enzymes — general meal digestion alongside histamine support
• Probiotics — supports overall gut health (choose low-histamine strains if sensitive)
• AOR Quercetin — a bioflavonoid often used in histamine-sensitivity routines
• Immune Support Supplements — broader immune and histamine wellness

💡 Subscribe & save up to 10% on every order — never run out of your daily supplements.

Compare Similar Products

• AOR Quercetin — Bioflavonoid used in histamine-sensitivity routines.
• All Digestive Enzymes — General digestive support.
• All Digestive Health Supplements — Browse digestive support.
• All Immune Support Supplements — Histamine and immune wellness.

About Vitamart

Vitamart.ca is Canada's vitamin specialist. We've been selling vitamins and supplements to Canadian families since 2005, shipping from our Ontario warehouse to every province. We believe in quality products you trust at prices you love — no fancy packaging markups, no pushy upsells, just the vitamins you need at the lowest prices in Canada. Backed by our Low Price Guarantee: find a lower advertised price at a Canadian competitor and we'll beat it by 1¢.

Vitamins Lowest Prices.

Adults: take 2 Xymogen HistDAO tablets 1 time per day. Take 15 minutes before a meal. Do not chew or break tablets. Swallow whole.