{"title":"Colostrum and Lactoferrin","description":"","products":[{"product_id":"sequence-colostrum-200mg-first-milking-rich-in-immune-and-growth-factors-90-lozenges","title":"Sequence Colostrum 200mg, First Milking, Rich in Immune and Growth Factors, (Formerly Sequel Colostrom) 90 Lozenges","description":"\u003cdiv data-content-type=\"html\" data-appearance=\"default\" data-element=\"main\"\u003e\n\u003ch2\u003e\r\n\t\u003cimg alt=\"Everyday Support for Optimal Well-Being Colostrum\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequel-colostrum-support-optimal-well-being.jpg\" style=\"width: 800px; height: 378px;\"\u003e\u003ch2\u003e\r\n\tSequence Colostrum Powder Details\u003c\/h2\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\r\n\tConvenient and great tasting, the lozenges are ideal for daily immune system enhancement and anti-aging protection. The whole family will love taking their colostrum in this yummy and effective delivery form! It is by far our most popular and affordable delivery system. \u003c\/p\u003e\n\u003ch3\u003e\r\n\tWhat is Colostrum?\u003c\/h3\u003e\n\u003cp\u003e\r\n\tLife’s perfect first food, colostrum is the pre-milk fluid produced by all female mammals prior to giving birth.\u003c\/p\u003e\n\u003cp\u003e\r\n\tNaturally rich in immune and growth factors, colostrum helps insure the health of the newborn. We all know newborns fare better when able to obtain colostrum through breastfeeding but did you know that people of all ages can benefit from taking colostrum? Colostrum has applications for every generation and it’s never too late to start receiving the benefits of life’s first food.\u003c\/p\u003e\n\u003cp\u003e\r\n\tSince collecting human colostrum is unrealistic, the next best source is bovine (cow) colostrum as it is nearly identical to that of human’s. In fact, research proves bovine colostrum can enhance immune system function and support growth and repair in all mammals, including humans. In addition, cows produce an abundance of colostrum, more than enough to supply human needs without depriving newborn calves.\u003c\/p\u003e\n\u003cp\u003e\r\n\tHistorically, bovine colostrum has played a significant role in natural healing. In India, Ayurvedic physicians have prescribed it for thousands of years and still do to this day. In western medicine, bovine colostrum was used extensively for immune purposes prior to the invention of antibiotics and sulfa drugs. In fact, did you know that the Polio vaccine was developed from antibodies isolated from bovine colostrum?\u003c\/p\u003e\n\u003cp\u003e\r\n\tOver the past few years, the scientific community has “rediscovered” this all natural immune and growth supporting food. Thousands of clinical and research studies have been published on the use of colostrum and its components to treat a variety of diseases and health concerns.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tBenefits of Colostrum\u003c\/h3\u003e\n\u003cp\u003e\r\n\tColostrum is truly nature’s perfect immune-enhancing and anti-aging superfood!\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe two main groups of components responsible for the beneficial effects of colostrum are immune factors and growth factors. These powerful, all-natural components work in concert to enhance immune system function and support cellular growth and repair.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAs we age, our bodies gradually produce less and less of these powerful immune and growth factors that help fight disease, repair body tissue and promote energy and vitality. With the decline of these components over time, we age until we eventually die. Colostrum is the only natural source of these life-supporting immune and growth factors!\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe immune factors in colostrum include antibodies that provide immunity from numerous microorganisms. Other immune factors work together to kill bacteria and viruses, regulate the thymus gland, control inflammation, protect against allergic reactions, balance and nourish the immune system.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe growth factors in colostrum are responsible for rebuilding and repairing cellular tissues. These growth factors also help to build lean muscle, increase at metabolism, improve nutrient uptake, improve memory and mood, increase skin elasticity, balance blood sugar levels and increase energy.\u003c\/p\u003e\n\u003cp\u003e\r\n\tDoes this all sound too good to be true? Few natural supplements have as much medical research supporting its value as colostrum. There are literally thousands of published clinical and scientific research studies proving the health-benefiting properties of colostrum. Here are just a few of the documented benefits of colostrum:\u003c\/p\u003e\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tEnhances overall immune system and helps boost natural resistance to illness and disease\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tProvides anti-viral, anti-bacterial and anti-fungal protection, creating unfavorable conditions for growth of numerous harmful microorganisms including those responsible for common health problems such as colds, influenza, diarrhea, ulcers, gum disease, and yeast infections\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tRegulates numerous auto-immune conditions including allergies, asthma, rheumatoid arthritis, lupus, multiple sclerosis, Alzheimer's disease\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tImproves state of chronic health problems such as diabetes, heart disease, colitis, irritable bowel, leaky gut syndrome, fibromyalgia, chronic fatigue, and HIV\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tActs as an antioxidant to reduce the damaging effects of free radicals\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tBinds and transports iron in the body and is beneficial for iron-deficiency anemia\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tHeals digestive system and enhances nutrient absorption\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tHelps speed healing of wounds\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tEnhances lean muscle mass and increases metabolism of body fat\u003c\/li\u003e\r\n\u003c\/ul\u003e\n\u003ch3\u003e\r\n\tProduction of Colostrum\u003c\/h3\u003e\n\u003ch4\u003e\r\n\tSource and Collection\u003c\/h4\u003e\n\u003cp\u003e\r\n\tThe source of colostrum is one of the most important factors to consider when evaluating different brands of colostrum. We encourage everyone to investigate fully the background of any colostrum product before administration.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAt Sequence, our first milking colostrum is obtained only from the finest local, small family dairy herds in North America. Appropriate collection receptacles are supplied to the dairy producers for saving first milking colostrum from healthy cows. This must be the cows' third or subsequent lactation. We only use colostrum collected within the first six hours after birth.\u003cbr\u003e\r\n\tImmediately after milking, the filled jugs are put in the producer's freezer and kept frozen until collection by a representative of our raw materials supplier, or in a few instances, delivered to the company plant by the producer. Colostrum must arrive at the company in a frozen state, unless freshly milked, where it is inspected by trained personnel and placed in a freezer and maintained at -5 degrees F +\/- 5 degrees.\u003c\/p\u003e\n\u003cp\u003e\r\n\tOur raw materials supplier has on file affidavits from each owner\/operator of contributing dairy farms, stating that their animals have not and are not being fed restricted proteins as set out in 21 CFR 589.2000. Each container of colostrum harvested from these dairies has also been recorded as having come from cows not fed illegal feeds.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tProcessing\u003c\/h4\u003e\n\u003cp\u003e\r\n\tProcessing of colostrum is the second most important factor in the quality of colostrum. Our raw materials supplier has developed its own means of processing colostrum and has an FDA approved proprietary pasteurization process that is more effective than standard pasteurization processes at maintaining biological activity. We also homogenize our product for uniformity.\u003cbr\u003e\r\n\tFirst milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. With the exception of our liquid, all our colostrum products have all naturally occurring fats intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe drying or dessication process is another important factor in maintaining biological activity. Our powder-based products are spray dried at low temperatures by indirect heat using proprietary equipment and processes. We know the length of time in seconds our product is in the drying process and the exact temperature that it reaches in this process. Our first milking colostrum powder maintains virtually all of its original bioavailibility throughout the manufacturing process.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tFinished Products\u003c\/h4\u003e\n\u003cp\u003e\r\n\tFinished products are exactly identified and stored at ambient temperature. Composite samples are evaluated for quality assurance and logged in permanent records. Sequel Natural’s genuine first milking bovine colostrum is produced using proprietary specifications and processes that assure the highest levels of biological activity, guaranteeing the greatest value for your dollar.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tQuality Assurance\u003c\/h4\u003e\n\u003cp\u003e\r\n\tFor your safety and peace of mind, all our colostrum products are made in GMP certified and\/or FDA licensed facilities under the strictest of quality standards. Every batch of product is tested and certified to be free of any harmful pathogens by independent laboratories.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tComponents of Colostrum\u003c\/h3\u003e\n\u003ch4\u003e\r\n\tGrowth Factors\u003c\/h4\u003e\n\u003cp\u003e\r\n\tBovine colostrum is naturally rich in powerful growth factors including Insulin-like growth factor 1 (IGF-1), transforming growth factor (TGF) and epithelial growth factor (EGF). These natural growth factors help slow down the effects of aging on a cellular level, resulting in benefits such as increased energy and vitality, greater lean muscle mass, increased fat metabolism and weight loss, improved memory and elevated mood.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tImmunoglobulins\u003c\/h4\u003e\n\u003cp\u003e\r\n\tImmunoglobulins and antibodies are one and the same. IgA, IgD, IgE, IgG and IgM are the most abundant of the immune factors found in bovine colostrum. IgG neutralizes toxins and microbes in the lymph and circulatory system, IgM destroys bacteria, while IgE and IgD are highly antiviral.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tLactoferrin\u003c\/h4\u003e\n\u003cp\u003e\r\n\tLactoferrin is one of the most powerful antiviral, antibacterial substances, found naturally, in bovine colostrum and human colostrum.\u003c\/p\u003e\n\u003ch4\u003e\r\n\tAdditional Components\u003c\/h4\u003e\n\u003cp\u003e\r\n\t\u003cstrong\u003eCytokines\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tCytokines are composed of Interlukins that regulate the intensity and duration of immune responses and are responsible for cell to cell communications. They boost T-cell activity, regulate lymph activity, stimulate production of immunoglobulins and elevation of immune activity and are antiviral and antibacterial.\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cstrong\u003eLactalbumin\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tThese are simple, highly nutritious proteins found in mother's milk and colostrum. \u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cstrong\u003eLactoperozidase-thiocyanate, plus Peroxidase and Xanthine Oxidase Enzymes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tThese have an antimicrobial activity and nonspecific immunity role such as oxidizing (burning up) bacteria by generating the release of hydrogen peroxide. These are the enzymes found in bovine colostrum. Together with hydrogen peroxide and thiocyanate, lactoperoxidase forms a potent natural antibacterial system called the lactoperoxidase system.  Karne J. Losnedahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology Antimicrobial Proteins in Milk, Illinois Dairy Report 1996.\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cstrong\u003eLysozyme\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tLysozyme is a powerful hydrolyzing agent, resistant to acids that destroy bacteria and viruses on contact. It is found in perspiration, saliva and tears. In recent years, it has been added to infant formula to boost immune capability. Karen J. Losnehahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology: Antimicrobial Proteins in Milk, Illinois Dairy Report, 1996.\u003c\/p\u003e\n\u003cp\u003e\r\n\tLysozyme kills bacteria by disrupting the formation of a glycosidic bond between the two components of peptoglycon, a constituent of the bacterial cell wall. Lysozyme possesses antibacterial activity against a number of bacteria. This enzyme usually functions in association with Lactoferrin or immunoglobulin A. Lysozyme is effective against Esherichia coli in concert with Immunoglobulin A (IgA).\u003c\/p\u003e\n\u003cp\u003e\r\n\tIt causes lysis of some species of salmonella in association with ascorbate and peroxide. Lysozyme can limit the migration of neutrophils into damaged tissue and might function as an anti-inflammatory agent.\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cstrong\u003eProline-Rich Polypeptide\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tProline-rich polypeptide (PRP) is a hormone in colostrum that regulates the thymus gland. PRP is an immunomodulator, meaning it can stimulate an underactive immune system as well as down-regulate an overactive immune system. This makes PRP an especially important component in the fight against autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, and allergies.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tImportance of Natural Fats\u003c\/h3\u003e\n\u003cp\u003e\r\n\tFirst milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. When purchasing colostrum, ensure all its naturally occurring fats are kept intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003e\r\n\tUnfortunately, most brands of colostrum have most of their fats removed. Removal of the natural fats from colostrum is primarily done for a number of reasons. The main purpose is to artificially elevate the IgG percentage in colostrum, thus making it \"appear\" to be harvested from the first or earlier collections. Another reason is to hide the rancid odor of poor quality, mishandled, or old colostrum. All else being equal, fat-free colostrum is more shelf stable and offers a longer shelf life. Lastly, fat-free colostrum mixes more easily with and dissolves more quickly in water.\u003c\/p\u003e\n\u003cp\u003e\r\n\tExcessive fat is a concern in our diets, as is cholesterol. Genuine first milking colostrum is very low in cholesterol, containing only 1.9 mg of cholesterol per gram of dried colostrum.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tImportance of Oral Delivery\u003c\/h3\u003e\n\u003cp\u003e\r\n\tUsing the proper delivery system is of great importance. The greatest benefits observed in scientific colostrum studies were achieved via oral delivery (absorption in the mouth). Colostrum absorbed in the oral cavity activates the entire body’s immune pathways to open to self-healing.\u003c\/p\u003e\n\u003cp\u003e\r\n\tBecause most infectious microorganisms enter the body through the nose or mouth, the oral cavity is specially designed with mucus membranes and salivary glands that secrete powerful immune components. The oral cavity is loaded with receptor sites which, when activated, alert the entire body through a complex chain reaction of immune system events. To maintain good health, it is critical that we are able to stop pathogens at their initial place of entrance and combat disease-causing organisms in the oral cavity before they travel further.\u003c\/p\u003e\n\u003cp\u003e\r\n\tExamples of oral delivery include taking liquid under the tongue, slowly dissolving a lozenge or eating\/drinking powder mixed with food\/beverage. Swallowing capsules is not an ideal form of delivery as it bypasses the key oral receptor sites and misses the natural protease inhibitors, buffers, mucous secretions, hormones, enzyme, sensors and receptors. Essentially, it is delivered into the stomach without protection of any kind.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe gelatin capsule is then dissolved and the full effects of the stomach acid are applied to the colostrum components. It then is exposed to the rather basic bile salts in the duodenum and throughout the entire small intestine before it reaches the Gut Associated Lymphoid Tissue (GALT) near our appendix, where the primary response of the capsule ingested colostrum comes about. Much of the colostrum components could now be altered or denatured, and dilute or render them less effective. To compensate, a much larger dose of colostrum would have to be consumed to produce the same effective results. A better alternative would be to open capsules and take the colostrum orally.\u003c\/p\u003e\n\u003cp\u003e\r\n\tLozenges, on the other hand, which are designed to be held inside the mouth for several minutes, are an ideal route for taking colostrum. Why? Because the oral cavity is the gate of entry into the body's communication network.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAs a child, calf, foal, puppy or kitten nurses colostrum floods the oro-nasal pharyngeal cavity exposing the secretion to the many receptor sites. These receptor sights form a variety of communication pathways that distribute signals to various parts of the body. Part of the pharyngeal region contains lymphoid cells, tonsils, referred to as MALT, Mucosal Associated Lymphoid Tissue. This is the same type of tissue as the lymphoid tissue near the illio-cecal valve termed as GALT.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe great advantage of MALT over GALT is that MALT is present early on, before any digestive processes start to alter the colostral components as in GALT. MALT is also protected by many of the buffers, enzymes, mucous and other protective properies so secreted by glands in the oro-naso pharyngeal lamina propria.\u003c\/p\u003e\n\u003cp\u003e\r\n\tImportance of First Milking\u003cbr\u003e\r\n\tWhile sometimes called “first milk”, colostrum is actually a pre-milk substance since milk is produced after colostrum. Birth is the event that stops colostrum production and triggers the creation of milk. All else being equal, the sooner after birth colostrum is collected, the higher its quality (measured as percentage of protein) and corresponding levels of immune and growth factors.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe highest quality colostrum is usually collected within the first six hours after birth. This is referred to as first milking colostrum and it is the closest thing to pure colostrum, which is only available immediately after birth. Colostrum from subsequent milkings, if blended with the first, compromises the delicate balance of immune and growth factors found only in first milking colostrum.\u003c\/p\u003e\n\u003cp\u003e\r\n\tOnly first-milking colostrum is ever used in clinical and scientific research studies as colostrum quality declines rapidly after birth. Colostrum harvested twelve hours after birth contains only about one-third of the immune and growth factors present at birth and after twenty-four hours, it is less than one-quarter of its original quality.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAs little as 125mg of genuine, first-milking colostrum delivered via the oral cavity is sufficient to trigger an immune response. Several times that amount may be required with conventional multiple-milking products. Most colostrum products on the market are a combination of the first five milkings, collected up to 48 hours after birth.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe following table shows how quickly the quality of colostrum declines after birth:\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cimg alt=\"Sequence Colostrum 200mg, 90 Lozenges\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequence-colostrum-quality-declines-after-birth.jpg\" style=\"width: 379px; height: 202px;\"\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\tAs you can see, time of harvest is of key importance in determining the quality of colostrum. If a product does not claim its source to be from only the first milking, likely it is not. Or, if it cannot back up its claims to be from only the first milking with a certificate of analysis done by an independent laboratory, it is likely not true first milking colostrum.\u003c\/p\u003e\n\u003cp\u003e\r\n\tGenuine first milking colostrum can cost several times as much as colostrum taken from a combination of subsequent milkings. Keep in mind that only the highest quality, first-milking colostrum is used in the thousands of clinical and scientific research studies. Colostrum collected from multiple milkings may not provide the desired results.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tScientific Definition of Colostrum\u003c\/h3\u003e\n\u003cp\u003e\r\n\tColostrum is the first lacteal secretion produced by the mammary glands of mammals at the beginning of lactation and is intended for ingestion by the newborn during the first hours of life. In most mammals, such as humans, many of the biologically active substances essential to development and survival, such as growth promoting substances and immunoglobulins, cross the placental barrier and are transferred to the fetus in utero. In sharp contrast, in bovine essentially none of these biologically active substances cross the placental barrier and, thus, must be acquired by the calf through suckling during the early hours of its life. As such, bovine colostrum represents a unique, concentrated resource for a wide variety of biologically active substances.\u003c\/p\u003e\n\u003cp\u003e\r\n\tColostrogenesis, the formation of colostrum, and lactogenesis, the process which mammary tissue undergoes when changing from a non-lactating to a lactating state, are events associated with pregnancy that are controlled by a specific complex of hormones and influenced by physical factors associated with the mammary gland. In the cow, development of mammary tissue and its ability to synthesize and produce secretions is promoted primarily by growth hormone and its mediators, the insulin-like growth factors IGF-1 and IGF-2 and the transforming growth factors TGF-beta 1 and TGF-beta 2. The process is regulated by a series of other hormones, one of the most important being progesterone, which attaches to special receptors on the cells lining the mammary gland and prevents them from secreting any fluids into the gland during most of pregnancy.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe formation of colostrum in the pregnant cow is initiated about 3-4 weeks before parturition (birth) when a limited amount of fluid is released into the developing mammary tissue containing small amounts of the growth factors and other transforming substances. These substances influence the appearance of specific receptors on the surface of the cells lining the mammary gland that will facilitate the transfer of materials from the mother's blood into the gland. The substances include, among others, the IgG (antibodies) necessary to convey passive immunity to the calf and various hormones and growth promoters required to induce development of the newborn calf.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAbout two weeks before birth, the receptors for IgG become fully active. IgG from the mother's blood attaches to the receptors and is transferred via special vessels through the cells into the fluid in the gland. The IgM and IgA found in colostrum are actually produced by cells (B cells) from the mother's immune system that have moved into the mammary tissue. These molecules are transferred into the fluid in the gland by a similar receptor mechanism. The additional receptors on the cells lining the mammary gland capable of transporting other substances become fully activated about 3-5 days before birth.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAbout 2 days before birth, the hormonal balance begins to shift when the mother's blood concentration of prolactin and glucocorticoid hormones increases sharply, overriding some of the inhibitory effects of progesterone. This initiates the production of copious secretions and switches on the ability of cells in the mammary tissue to synthesize various substances, including lactose.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAt birth, when the placenta is eliminated, progesterone levels fall dramatically in the mother and its inhibitory control of the secretions is removed. Simultaneously, a protein-based substance develops in the cells lining the mammary gland that essentially blocks any further transfer of substances from the mother's blood into the gland.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe composition of the fluid in the mammary gland at birth is that of true colostrum and reflects the functional changes that have occurred in the gland up to that time; it a) has a high protein concentration, most of which is IgG; b) contains the highest concentration of growth promoters, other hormones and additional metabolically active substances; c) is low in lactose content; and d) is rich in milk fat.\u003c\/p\u003e\n\u003cp\u003e\r\n\tIn addition to containing a high concentration of maternally-derived immunoglobulins, first milking bovine colostrum contains a number of other biologically active substances. Although all of these substances have not as yet been characterized, many of the seemingly most important ones have been identified, including, among others, the following:\u003c\/p\u003e\n\u003cp\u003e\r\n\tInsulin-like growth factors that act on various metabolic processes that affect the uptake of glucose to derive a source of energy and utilization of amino acids to build proteins by cells in the body.\u003cbr\u003e\r\n\tSubunits of the hormone thymosin that act independently and in concert on the thymus gland to stimulate development and activation of the immune system.\u003cbr\u003e\r\n\tCytokines that stimulate the development and activation of various cells associated with the immune system.\u003cbr\u003e\r\n\tLactoferrin and transferrin, which are proteins that bind iron and act primarily in the gut to impede the growth of certain potentially pathogenic aerobic bacteria, like E. coli.\u003cbr\u003e\r\n\tXanthine oxidase and lactoperoxidase, which are enzymes that can inhibit the growth of certain potentially pathogenic bacteria in the gut.\u003c\/p\u003e\n\u003cp\u003e\r\n\tAfter birth, one of the most influential factors on the composition of subsequent secretions is physical removal of the fluid from the mammary gland. The removal of even small quantities of fluid triggers the production of copious amounts of secretion from the cells in the mammary gland.\u003c\/p\u003e\n\u003cp\u003e\r\n\tSince the transfer of biologically-active substances from the mother's blood is blocked, replacement fluid will contain primarily substances synthesized by cells in the mammary gland and, thus, will be of a different composition than the fluid originally contained in the mammary gland at birth. This fluid is known as transitional milk. The more original fluid, which is true colostrum, that is removed, the more adulterated the residual fluid becomes with transitional milk.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThis becomes more complex since the mother's system will begin to reabsorb certain of the biologically-active substances, including some of the hormones and the immunoglobulins, from the mammary gland back into her bloodstream within 6-8 hours after birth of her calf. Therefore, the composition of the mammary secretions changes rapidly during the hours and days after birth so that there is a continuous transition from true colostrum to mature milk.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe average yield of colostrum taken from a mature Holstein dairy cow during the first six hours after birth will be approximately ten liters. This removes about 80% of the true colostrum while the remaining 20% usually cannot be milked out during this period due to the normal congestion of the udder of the mother. After removal of the first harvest, the udder quickly fills with \"transitional milk\", which is lower in fat and protein and higher in lactose.\u003c\/p\u003e\n\u003cp\u003e\r\n\tThe milking taken during the 6-12 hour period after birth again removes about 80% of the lacteal secretions present in the udder, including the 20% residual from the first milking. Again, 20% of this \"colostral\" material remains and is further diluted as the udder refills with \"transitional milk\". The only unadulterated true colostrum is, therefore, derived upon harvesting the first milking from the mother within six hours after birth and before the calf has suckled.\u003c\/p\u003e\n\u003cp\u003e\r\n\tTo assure that calves receive sufficient quantities of high quality true colostrum, most dairy producers in the United States do not allow the calf to suckle its mother immediately after birth, but prefer to physically remove the true colostrum, and feed the required amount by nursing bottle. The remainder of this material is what is then used to make colostrum products for human consumption.\u003c\/p\u003e\n\u003ch3\u003e\r\n\tWhat Doctors are Saying\u003c\/h3\u003e\n\u003cp\u003e\r\n\t“Antibodies in bovine colostrum are able to neutralize the most harmful bacteria, viruses, and yeasts.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDr. Brandtzaeg; Annals of the New York Academy of Sciences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Immunoglobulin in colostrum has been used to successfully treat: Thrombocytopenia, Anemia, Neutropenia, Myasthenia Gravis, Guillain Barre, Multiple Sclerosis, Systemic Lupus, Rheumatoid Arthritis, Bullous Pemphigoid, Kawasaki’s Syndrome, Chronic Fatigue, Crohn’s disease, among others.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDr. Dwyer; New England Journal of Medicine\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Insulin-like Growth Factor 1 (IGF-1), found in bovine colostrum, stimulates bone and muscle growth and nerve regeneration. Also found: topical administration to wounds resulted in more effective healing.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDrs. Skottne, et al; Paediatric Scandinavia, Sweden\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Clinical studies show that immunoglobulin found in bovine colostrum, may be responsible for regulating allergic response.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDrs. Tortora, et al; Microbiology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Proline Rich Polypeptide (PRP) in bovine colostrum has the same ability to regulate activity of the immune system as hor- mones of the Thymus gland. It activates an underactive immune system and also suppresses an overactive immune system, such as is often seen in the autoimmune diseases.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDrs. Staroscik, et al; Molecular Immunology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Colostrum contains significant amounts of Interlukin-10 (a strong inflammation inhibitory agent), found significant in reduc- ing inflammation in arthritic joints and injury areas.\"\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDr. Olle Hernell, Univ. of Ulmea, Sweden; Science\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\r\n\t \u003c\/p\u003e\n\u003cp\u003e\r\n\t“Lactoferrin, a glycoprotein in colostrum, can bind free iron with high affinity and thus function as a local antioxidant, protecting immune cells against free radicals.”\u003c\/p\u003e\n\u003cp\u003e\r\n\t\u003cspan style=\"font-size:10px;\"\u003eDr. Britigan, et al; Advances in Experimental Medicine and Biology\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/div\u003e","brand":"Sequence","offers":[{"title":"Default Title","offer_id":42621931749547,"sku":"SEQ00101\/699110-DiscoSupplier","price":29.97,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/products\/sequence-colostrum-lozenge-90_acc176b1-594b-4361-b94a-661dc53243ae.jpg?v=1710970208"},{"product_id":"organika-colostrum-bovine-500mg","title":"Organika Colostrum, Bovine, 500mg Capsules","description":"\u003ch2\u003eOrganika Colostrum (Bovine) 500mg Details\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports optimal immune system function.\u003c\/li\u003e\n\u003cli\u003eObtained from Grade A dairy cattle. \u003c\/li\u003e\n\u003cli\u003eSpecialized processing maintains bioactive efficacy.\u003c\/li\u003e\n\u003cli\u003eSafe for both adults and children.\u003c\/li\u003e\n\u003cli\u003eEasy to swallow capsule form.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eContaining immune boosting immunoglobulins \u0026amp; lactoferrin, Organika's pure colostrum can help to optimize your both your immune \u0026amp; digestive systems. Easy to swallow capsule.\u003c\/p\u003e\n\u003ch3\u003eWhat is Organika Colostrum?\u003c\/h3\u003e\n\u003cp\u003eColostrum is the “first food of life” because it is excreted from the mammalian breast during the first 72 hours after birth.  It is rich in nutrients and substances called immunoglobulins and lactoferrin.  Immunoglobulins and lactoferrin support the maturation of the immune system, a process that is not completed until the second year of life in humans. They are antimicrobial, anti-allergenic and protective against toxins.  Natural health practitioners for a variety of conditions including colds and flus, chronic and frequent infections, wounds, burns, ulcers, diarrhea, intestinal inflammation, weight management and blood sugar imbalances recommend colostrum.\u003c\/p\u003e\n\u003ch3\u003eImmune System Health\u003c\/h3\u003e\n\u003cp\u003eThe immune system is the police force of the body.  It is a complex system of cells that defend the body from invading organisms, regulate inflammation and control abnormal cell growth.  Many organs are involved in the immune response, the bone marrow, lymphatic system, thymus, liver and spleen.  Bone marrow produces red blood cells, white blood cells and platelets.\u003c\/p\u003e\n\u003cp\u003eThe spleen is a location where immune cells can monitor the blood for foreign matter.  It also speeds up red blood cell production and activates blood clotting. The liver can increase body temperature and induce sweating to help fight off infections.  The thymus produces B cells, which make antibodies, and T cells, which are part of the immune response.\u003c\/p\u003e\n\u003cp\u003eThe immune system is capable of fighting off intruders and remembering them so that they are killed off quickly if they invade again.  The immune system must be able to differentiate self from non-self in order to know what to attack.  If it does not recognize the body’s own tissue than autoimmune diseases occurs.\u003c\/p\u003e","brand":"Organika","offers":[{"title":"90 Capsules","offer_id":42622005018795,"sku":"1568-DiscoVitamart","price":27.55,"currency_code":"CAD","in_stock":false},{"title":"180 Capsules","offer_id":42622005051563,"sku":"1569","price":53.59,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/1569-organika-colostrum-2000mg-180-capsules-min.jpg?v=1761586160"},{"product_id":"now-colostrum-500mg","title":"NOW Colostrum 500mg, 120 Capsules","description":"\u003ch2\u003e\r\n\tNOW Colostrum Details\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tRich in Immunoglobulins and Lactoferrin\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tAverage of 25%  IgG Antibodies\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tA Dietary Supplement\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tNaturally Occurring Immunoglobulins and Lactoferrin\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\r\n\tColostrum is the nourishing fluid produced by mammals as food for the newborn in the few days after birth, before milk production begins.  This bovine-derived food supplement is rich in a variety of biologically active proteins, including immunoglobulins, Lactoferrin, and other factors that support the maintenance of lean muscle tissue, as well as a healthy immune system.  Scientific studies have shown that Colostrum helps to increase bioavailability and absorption of nutrients into the body, while encouraging healthy gastrointestinal function.\u003c\/p\u003e\r\n","brand":"NOW","offers":[{"title":"Default Title","offer_id":42622067540139,"sku":"NOW83216-DiscoSupplier","price":25.97,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/NOW83216-now-colostrum-500mg-120-vegetable-capsules-1-min.jpg?v=1751641101"},{"product_id":"aor-advanced-whey","title":"AOR Advanced Whey Protein, Enhanced with Lactoferrin, Non-GMO, 1kg","description":"\u003ch2\u003eAOR Advanced Whey Protein Details\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnriched with lactoferrin, high in alpha-lactalbumin\u003c\/li\u003e\n\u003cli\u003eProvides 5 g of BCAA per serving\u003c\/li\u003e\n\u003cli\u003eBoosts the immune system\u003c\/li\u003e\n\u003cli\u003ePromotes healthy cellular growth\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAOR Advanced Whey is no regular whey protein. It combines whey protein isolate with a high-protein concentrate (76% protein), which offers benefits not associated with whey protein isolate alone. A quality whey protein supplement like AOR Advanced Whey consists of about 20% alpha-lactalbumin. AOR Advanced Whey is also enriched in lactoferrin, containing up to 28% more lactoferrin than other high-end whey proteins currently available. Lactoferrin levels increase naturally after intense bouts of physical activity. This response enhances the immune system which can be weakened by rigorous exercise. AOR Advanced Whey uses cross-flow microfiltration (not ion-exchange) to maximize protein content and minimize unnecessary carbohydrate and saturated fat while retaining all bioactive peptide subfractions. The low temperature, filtration-based processing techniques used in these materials allow absolute minimal protein denaturation.\u003c\/p\u003e\n\u003cp\u003eAOR Advanced Whey isn’t your average protein powder.  It is a high-quality whey protein designed to capitalize on the benefits of immune-supporting nutrients naturally found in whey. The combination of whey protein concentrate rich in alpha-lactalbumin, whey protein isolate and lactoferrin isolate results in a protein that is 20% alpha-lactalbumin and contains up to 28% more lactoferrin than other high-end whey proteins currently available. Advanced Whey is now made without the use of soy-based ingredients.  \u003c\/p\u003e\n\u003cp\u003eWhey protein is an excellent addition to a lactovegetarian diet or any diet that is lacking in protein.  It is often used as a weight loss food, and also provides valuable support for muscle building and maintenance, whether in the gym or for the elderly and frail. \u003c\/p\u003e\n\u003cp\u003eThe widespread health applications of whey protein are heavily dependent on its lactoferrin and alpha-lactalbumin content. Recent findings indicate that lactoferrin suppresses inflammation and reduces cholesterol levels. Scientists have determined that lactoferrin stimulates anti-inflammatory cytokines and inhibits pro-inflammatory cytokines. Lactoferrin's effects on cholesterol levels seem to be based on its ability to reduce the oxidation of LDL cholesterol, an important function considering that oxidized LDL cholesterol can damage artery walls and set the stage for mineral and fat deposits which lead to blockages. Lactoferrin's multifunctional role also encompasses antibacterial, antiviral, antifungal, antioxidant and immunomodulatory activities. \u003c\/p\u003e\n\u003cp\u003eAOR Advanced Whey is good for those who want to boost their immunity, build muscle or lose weight, and is a good source of nutrition for those who may not consume enough protein in their diets.\u003c\/p\u003e","brand":"AOR","offers":[{"title":"1kg \/ Light Vanilla","offer_id":42622192582827,"sku":"AOR04130","price":76.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/AOR04130-aor-advanced-whey-with-lactoferrin-light-vanilla-flaour-1kg-min.jpg?v=1725509730"},{"product_id":"aor-all-life-colostrum","title":"AOR All-Life Colostrum, 500mg, 120 Vegi-Capsules","description":"\u003ch2\u003e\r\n\tAOR All-Life Colostrum Details\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tHelps fight disease and infection\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tDelivers compounds for a strong immune system\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tHarmonizes the immune system to avoid autoimmune disease\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\r\n\tAll-Life Colostrum is collected and processed within 12 hours of calving from American pasture cows. Higher quality colostrum is extracted from cattle exposed to severe temperature changes since this results in higher immune factor production. All-Life Colostrum has been purified of all but trace quantities of lactose and is freeze dried to preserve the biological activity of its special proteins. All-Life Colostrum helps to support the immune system.\u003c\/p\u003e\r\n","brand":"AOR","offers":[{"title":"Default Title","offer_id":42622194942123,"sku":"AOR04295","price":38.7,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/products\/AOR-All-Life-Colostrum-500mg-120-Vegi-Capsules-01_b9e5e452-c9f3-468f-a10e-bfeabc913f7a.jpg?v=1716073808"},{"product_id":"aor-lactoferrin-ultra","title":"AOR Lactoferrin Ultra, 1kg Powder (Call us to place an order)","description":"\u003ch2\u003e\r\n\tAOR Lactoferrin Ultra Details\u003c\/h2\u003e\r\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tEnhances the immune system\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tFights abnormal cellular growth and differentiation\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tBlocks bacterial and viral growth\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tIncreases levels of antioxidants\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\r\n\tLactoferrin Ultra combines an ultra-high dose of lactoferrin with whey protein isolate and a high-protein concentrate (76% protein). Lactoferrin is a minor whey protein fraction. In humans, lactoferrin levels increase naturally after intense bouts of physical activity. This response enhances the immune system which can be weakened by rigorous exercise.\u003c\/p\u003e\r\n\u003cp\u003e\r\n\tLactoferrin Ultra is a source of essential and branched chain amino acids for protein synthesis and of protein which helps build antibodies and build and repair body tissues. Lactoferrin-Ultra uses cross-flow microfiltration (not ion-exchange) to maximize protein content and minimize unnecessary carbohydrate and saturated fat while retaining all bioactive peptide subfractions. The low temperature, filtration-based processing techniques used in these materials allow absolute minimal protein denaturation.\u003c\/p\u003e\r\n\u003cdiv\u003e\r\n\tThose requiring powerful immune system support and supplementary protein during weakened conditions and illness will greatly benefit from adding Lactoferrin Ultra to their diet. \u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\tLactoferrin is an iron-binding glycoprotein found in human milk and bovine milk that has powerful immune boosting effects. Its multifunctional role also encompasses antibacterial, antiviral, antifungal, antioxidant, and immunomodulatory activities. Neonatal units successfully use lactoferrin to help reduce infection in hospitals, and baby formulas manufactured in China are now being supplemented with lactoferrin. Being an immunomodulator, lactoferrin helps manage the inflammatory response. Inflammatory conditions that can benefit from lactoferrin include high cholesterol, gastrointestinal inflammation, respiratory tract inflammation and acne. Lactoferrin may also stimulate the cells responsible for bone growth.\u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\t \u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\tAnimal studies confirm that the combination of lactoferrin and chemotherapy is more effective than either treatment alone. Lactoferrin can therefore be used to increase the effectiveness of conventional treatments and also to prevent secondary infections. This is a significant advantage because infections secondary to immune dysfunction are a leading cause of mortality in patients receiving radiation or chemotherapy treatments. Lactoferrin Ultra contains 89% protein by weight. In cancer patients, the ability to maintain adequate nutrition is essential for a favorable prognosis, and proteins are particularly important to prevent the development of cancer cachexia, a condition characterized by weight loss, muscular atrophy, weakness, and anorexia.\u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\t \u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\tLactoferrin Ultra is an advanced whey protein formula designed to support and enhance the immune system. It is composed of a mixture of whey protein isolate and whey protein concentrate, high in alpha-lactalbumin, to which a high dose of bovine lactoferrin has been added. While lactoferrin makes up only about 1% of the total protein content in most whey proteins products, AOR’s Lactoferrin Ultra contains a whopping 20%.\u003c\/div\u003e\r\n","brand":"AOR","offers":[{"title":"Unflavoured","offer_id":42622207066283,"sku":"AOR04159","price":596.48,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/products\/AOR-Lactoferrin-Ultra-1kg-Powder-01_1fcd0952-c7fa-41e6-86fe-e4907344f119.jpg?v=1716074282"},{"product_id":"aor-lactoferrin-250","title":"AOR Lactoferrin-250, 250mg, 60 Vegi-Capsules","description":"\u003ch2\u003eAOR Lactoferrin-250 Details\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eAOR Lactoferrin-250\u003c\/strong\u003e delivers 250 mg of pure lactoferrin per capsule — a multifunctional protein naturally found in mammalian milk and key bodily secretions. Lactoferrin is most-researched for its roles in immune support, iron metabolism, gut microbiome support, and inflammatory response modulation. It works differently from most immune supplements: rather than activating immune response, lactoferrin binds free iron in the body, making it less available to harmful bacteria while supporting healthy iron absorption. Made in Canada by AOR. 60 vegetable-capsules.\u003c\/p\u003e\n\n\u003cp class=\"vitamart-trust-strip\"\u003e\u003cstrong\u003eVitamins Lowest Prices\u003c\/strong\u003e  |  \u003ca href=\"https:\/\/www.vitamart.ca\/pages\/low-price-guarantee\"\u003eLowest Price in Canada — Guaranteed\u003c\/a\u003e  |  Ships from Ontario across Canada\u003c\/p\u003e\n\n\u003ch3\u003eQuick Facts\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLactoferrin per capsule\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e250 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCommon uses\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eImmune support, iron metabolism, gut microbiome, inflammatory response\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBottle size\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e60 vegetable capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAOR — practitioner-trusted Canadian brand\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMade in\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCanada\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDiet\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eVegetable capsules. Note: lactoferrin itself is dairy-derived.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBest taken\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eDaily on an empty stomach for absorption\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eWho AOR Lactoferrin-250 Is For\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAdults wanting immune support that works through a different mechanism than vitamin C, zinc, or elderberry\u003c\/li\u003e\n\u003cli\u003ePeople with low ferritin or iron metabolism concerns whose practitioner has recommended lactoferrin\u003c\/li\u003e\n\u003cli\u003eAdults focused on gut microbiome health — lactoferrin supports beneficial bacteria while limiting harmful ones\u003c\/li\u003e\n\u003cli\u003eWomen with iron concerns who can't tolerate iron supplements but want iron-metabolism support\u003c\/li\u003e\n\u003cli\u003eAnyone interested in a multifunctional immune-and-iron support protein with research backing\u003c\/li\u003e\n\u003cli\u003ePeople wanting AOR's practitioner-tier quality in the lactoferrin category\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWho this product is NOT for:\u003c\/strong\u003e If you have a milk protein allergy, do NOT use lactoferrin — it's a dairy-derived protein and can trigger allergic reactions. If you have hemochromatosis (iron overload) or take iron-modifying medications, consult your healthcare practitioner before use. If you mainly want general immune support, vitamin C, zinc, and vitamin D have more accessible cost and established research. If you have a severe iron deficiency requiring treatment, lactoferrin supports iron metabolism but is not a substitute for prescribed iron treatment — work with your practitioner. If you're vegan or strictly avoid dairy products, lactoferrin is dairy-derived and isn't appropriate.\u003c\/p\u003e\n\n\u003ch3\u003eVitamart's Take\u003c\/h3\u003e\n\u003cp\u003eAOR Lactoferrin-250 is a lactoferrin supplement designed to support immune health and healthy iron metabolism. Lactoferrin is a unique ingredient that offers a different approach from more traditional immune-support supplements. A quality formula from AOR, a trusted Canadian brand known for its science-based approach to formulation.\u003c\/p\u003e\n\n\u003ch3\u003eHow AOR Lactoferrin Compares\u003c\/h3\u003e\n\n\u003ch4\u003eLactoferrin vs Standard Iron Supplements\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eLactoferrin (this product):\u003c\/strong\u003e Supports iron metabolism without adding elemental iron. Gentler on digestion than iron tablets.\u003cbr\u003e\n\u003cstrong\u003eStandard Iron Supplements:\u003c\/strong\u003e Direct iron supplementation. Higher per-capsule dose. A fit for diagnosed iron deficiency requiring elemental iron repletion. Often combined with lactoferrin in practitioner protocols.\u003c\/p\u003e\n\n\u003ch4\u003eLactoferrin vs Vitamin C + Zinc Stack\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eLactoferrin (this product):\u003c\/strong\u003e Multifunctional protein with iron-binding and gut microbiome effects. Targeted use.\u003cbr\u003e\n\u003cstrong\u003eVitamin C + Zinc Stack:\u003c\/strong\u003e Established daily immune support. Lower cost. More research backing for general immune wellness. A fit for everyday daily immune routines.\u003c\/p\u003e\n\n\u003ch4\u003eLactoferrin vs Colostrum\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eLactoferrin (this product):\u003c\/strong\u003e Pure isolated lactoferrin at a defined dose.\u003cbr\u003e\n\u003cstrong\u003eColostrum:\u003c\/strong\u003e Contains lactoferrin alongside immunoglobulins, growth factors, and other compounds. A fit if you want broader colostrum benefits in addition to lactoferrin.\u003c\/p\u003e\n\n\u003ch3\u003eWhat Is Lactoferrin?\u003c\/h3\u003e\n\u003cp\u003eLactoferrin is a naturally occurring protein found in mammalian milk, tears, saliva, and other bodily fluids. Here's what's worth knowing:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMultifunctional protein:\u003c\/strong\u003e Lactoferrin has multiple roles — iron binding, antimicrobial activity, immune support, and gut microbiome modulation. Few supplements have this breadth of function in one molecule.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHow it works with iron:\u003c\/strong\u003e Lactoferrin binds free iron in the gut and bloodstream. This serves two purposes: (1) limiting iron availability to harmful bacteria that need iron to multiply, and (2) supporting controlled iron absorption for human cells and beneficial bacteria.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGut microbiome support:\u003c\/strong\u003e By controlling iron availability, lactoferrin selectively limits harmful bacteria while supporting beneficial bacteria that don't depend on free iron the same way.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune support:\u003c\/strong\u003e Lactoferrin is part of the innate immune system — your first line of defense. Supplemental lactoferrin may support these defenses, particularly for adults with compromised immune status.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Commercial lactoferrin is typically isolated from cow's milk (bovine lactoferrin). It's a dairy-derived protein — not suitable for milk-allergic individuals or vegans.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest on empty stomach:\u003c\/strong\u003e Lactoferrin is a protein that can be partially broken down by digestion. Empty-stomach dosing allows more intact lactoferrin to reach the gut and be absorbed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eHow To Use\u003c\/h3\u003e\n\u003cp\u003eAdults: Take 1 capsule daily on an empty stomach, or as directed by your healthcare practitioner. Empty-stomach timing (30 minutes before meals or 2 hours after) supports better absorption of intact lactoferrin. Talk to a healthcare practitioner if you're working with a specific protocol that requires different dosing.\u003c\/p\u003e\n\u003cp\u003eTalk to a healthcare practitioner before use if you have a milk protein allergy (do not use), hemochromatosis (iron overload), take iron-modifying medications, or have a chronic medical condition. Most adults tolerate lactoferrin well. Discontinue if you experience signs of allergic reaction.\u003c\/p\u003e\n\n\u003ch3\u003eFrequently Asked Questions\u003c\/h3\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eWhat is lactoferrin used for?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003eLactoferrin has four main research-supported uses: immune support, iron metabolism support, gut microbiome modulation, and healthy inflammatory response. It's a multifunctional protein, so it shows up in protocols where multiple of these support areas are relevant.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eWill it help with low iron?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003eLactoferrin supports iron metabolism by improving controlled iron absorption and limiting iron availability to harmful bacteria. It's not the same as taking elemental iron — it doesn't directly add iron to your body. For diagnosed iron deficiency requiring iron repletion, work with your practitioner; lactoferrin may be a complementary part of that protocol, not a replacement for prescribed iron.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eCan vegans take it?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003eNo — commercial lactoferrin is isolated from cow's milk. It's a dairy-derived protein and isn't suitable for vegans. For plant-based immune support, vitamin C, zinc, vitamin D, and medicinal mushrooms are alternatives.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eWhy empty stomach?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003eLactoferrin is a protein that can be partially broken down by digestion. Taking it on an empty stomach (30 minutes before meals or 2 hours after) allows more intact lactoferrin to reach the gut and be absorbed in its functional form.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eHow does it differ from vitamin C or zinc for immune support?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003eVitamin C and zinc are vitamins and minerals that support immune cell function and the body's response. Lactoferrin is a protein that works through different mechanisms — iron binding, antimicrobial activity, and microbiome support. They're complementary rather than substitutes. For everyday immune routines, vitamin C and zinc are more cost-effective; lactoferrin is targeted for specific protocols.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails\u003e\n\u003csummary\u003e➕ \u003cstrong\u003eWill it interact with my medications?\u003c\/strong\u003e\u003c\/summary\u003e\n\u003cdiv\u003ePossibly. Lactoferrin can interact with iron-modifying medications, certain antibiotics, and immunosuppressants. Talk to your healthcare practitioner before starting if you take any medications, especially for iron management.\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003ch3\u003ePairs Well With\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/probiotics\"\u003eProbiotics\u003c\/a\u003e — lactoferrin and probiotics both support gut microbiome health\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/iron\"\u003eIron Supplements\u003c\/a\u003e — if also addressing iron deficiency under practitioner guidance\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/products\/vitacheck-vitamin-c-1000mg-100-pure-180-delayed-release-capsules\"\u003eVitacheck Vitamin C\u003c\/a\u003e — supports iron absorption and immune function\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/immune-support\"\u003eImmune Support Supplements\u003c\/a\u003e — broader immune-support routine\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e💡 Subscribe \u0026amp; save up to 10% on every order — never run out of your daily supplements.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003ch3\u003eCompare Similar Products\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/colostrum-and-lactoferrin\"\u003eAll Lactoferrin \u0026amp; Colostrum\u003c\/a\u003e — Browse lactoferrin and colostrum products.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/iron\"\u003eAll Iron Supplements\u003c\/a\u003e — Browse iron-related products.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/immune-support\"\u003eAll Immune Support Supplements\u003c\/a\u003e — The full immune-support category.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.vitamart.ca\/collections\/probiotics\"\u003eAll Probiotics\u003c\/a\u003e — Browse gut microbiome support options.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eAbout Vitamart\u003c\/h3\u003e\n\u003cp\u003eVitamart.ca is Canada's vitamin specialist. We've been selling vitamins and supplements to Canadian families since 2005, shipping from our Ontario warehouse to every province. We believe in \u003cstrong\u003equality products you trust at prices you love\u003c\/strong\u003e — no fancy packaging markups, no pushy upsells, just the vitamins you need at the lowest prices in Canada. Backed by our \u003ca href=\"https:\/\/www.vitamart.ca\/pages\/low-price-guarantee\"\u003eLow Price Guarantee\u003c\/a\u003e: find a lower advertised price at a Canadian competitor and we'll beat it by 1¢.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamins Lowest Prices.\u003c\/strong\u003e\u003c\/p\u003e","brand":"AOR","offers":[{"title":"Default Title","offer_id":42622207197355,"sku":"AOR04110","price":77.55,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/products\/AOR-Lactoferrin-250-250mg-60-Vegi-Capsules-01_8214e97e-327a-4097-90cb-fea2a3f8b295.jpg?v=1716073813"},{"product_id":"provita-activine-anti-aging-60-caps","title":"Provita Activine, Anti-Aging Colostrum and Alpha-GCP, 60 Capsules","description":"\u003ch2\u003e\r\n\tProvita Activine Details\u003c\/h2\u003e\r\n\u003cdiv\u003e\r\n\tAs we age, our body loses its capacity to maintain proper protein synthesis function needed for maintaining healthy musculature. Healthy internal muscles (not visible) are specifically important for maintaining proper organ function such as heart, bowel movement etc. Skeletal muscles support the skeleton and are essential for maintaining our younger looking posture, body movement capacity and even the way we look.\u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\t \u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\tActivine™ is an anti-aging combination of amino-acids curated to specifically support muscle health. Our formulation is enforced with:\u003c\/div\u003e\r\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tColostrum – for improved immune function, and\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tAlpha-GPC – known for its cognitive benefits and stimulation of the pituitary gland.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cdiv\u003e\r\n\tAlpha-GPC enhances the brain’s metabolic pathways to promote natural energy production by optimizing mitochondrial efficiency while avoiding post-excitement crashes unlike caffeine and other stimulants.\u003c\/div\u003e\r\n\u003cdiv\u003e\r\n\t \u003c\/div\u003e\r\n\u003ch3\u003e\r\n\tProvita Activine Features and Benefits\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\t\u003cli\u003e\r\n\t\tAnti-Aging othomolecular formulation:\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tImproved muscle function\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tImproved posture\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tImproved mental calm\u003c\/li\u003e\r\n\t\u003cli\u003e\r\n\t\tImproved sleep through relaxation\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n","brand":"Provita Nutrition","offers":[{"title":"Default Title","offer_id":42622996709547,"sku":"25331011-60","price":54.54,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/25331011-60-provita-nutrition-activine-60-vegetable-capsules.jpg?v=1768933634"},{"product_id":"canadian-protein-colostrum-powder","title":"Canadian Protein Colostrum Powder","description":"\u003ch2\u003eCanadian Protein Colostrum Powder Description\u003c\/h2\u003e\u003cp\u003eColostrum Powder (Bovine), rich in antibodies, is an easily absorbed nutrient dense supplement that provides many health and well-being benefits such as strengthening of the immune system, promotes digestive health, and for bodybuilders, increased muscle mass and improved fat loss.\u003c\/p\u003e\u003cp\u003eColostrum, or bovine colostrums, as it is sometimes known, is a form of protein that is quite unlike any other you may be familiar with. Bovine colostrum is best described as being a pre-milk fluid that is secreted from cows around 2 – 4 days after the cows give birth to their young. This colostrum is not only rich in protein, it is also packed full of antioxidants, minerals, vitamins, amino acids, and other nutrients that do a whole world of good for the human body. Basically, when milk is considered to be at its most nutrient rich, this is referred to as colostrum, making it rich in nutrients. For example, the colostrum is rich in antibodies, including immunoglobulin G, providing overall health and wellness benefits.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHow does it work?\u003c\/strong\u003e\u003cbr\u003eThis supplement works in a number of different ways, because it provides so many health and well-being benefits. To begin with, the antibodies and nutrients in the supplement help to strengthen and boost the immune system, which obviously then provides overall health and well-being benefits in the process. It is also packed full of amino acids and proteins however, making it a very popular bodybuilding supplement. These proteins and amino acids help to promote increases in lean muscle growth and repair, and they also help to naturally stimulate the synthesis of muscle proteins, in the form of protein synthesis, which again, is essential from a rest and recovery standpoint. What’s more, colostrum is also beneficial from a gastrointestinal point of view, as once consumed, the natural antibodies and nutrients get to work on neutralising harmful bacteria within the digestive tract, which can help to alleviate conditions such as diarrhea and stomach ache, and poor nutrient absorption.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat are the benefits of using Colostrum supplements?\u003c\/strong\u003e\u003cbr\u003eSome of the primary benefits associated with bovine colostrum include the following:\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eImproved overall health\u003c\/strong\u003e\u003cbr\u003eAs this pre-milk supplement is basically a form of super-nutrient enriched milk, it provides a number of health and well-being benefits, due to the natural nutrient contents. For example, the antibodies and antioxidants help to boost the immune system, which in turn will provide additional protection against a whole host of various ailments.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eImproved digestive health\u003c\/strong\u003e\u003cbr\u003eAs mentioned, another benefit of this supplement, is the fact that it has been proven to neutralise harmful bacteria found living within the digestive tract, and it can therefore provide optimal digestive health. Conditions such as diarrhea, ulcerative bowel troubles, poor nutrient absorption, and many more, can all be alleviated as a result of this supplement.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIncreased muscle mass\u003c\/strong\u003e\u003cbr\u003eA lot of bodybuilders also supplement with bovine colostrum, as the supplement is rich in amino acids, nutrients, and proteins, which are vital for the growth and repair of muscle tissue. What’s more, as they can also help to enhance the metabolism, you will often find that you will burn fat, whilst building lean muscle at the same time.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMore muscle\u003c\/li\u003e\n\u003cli\u003eNutrient dense\u003c\/li\u003e\n\u003cli\u003eEasily absorbed\u003c\/li\u003e\n\u003cli\u003eStrengthens the immune system\u003c\/li\u003e\n\u003cli\u003eMore energy\u003c\/li\u003e\n\u003cli\u003eImproved digestive health\u003c\/li\u003e\n\u003cli\u003eAnd more...\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Canadian Protein","offers":[{"title":"100g","offer_id":42623213568171,"sku":"100g","price":29.99,"currency_code":"CAD","in_stock":false},{"title":"454g","offer_id":42623213600939,"sku":"454g","price":99.99,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/products\/canadian-protein-colostrum-powder-454g_ab704e32-318e-4636-9258-55fe26801fc9.jpg?v=1716075301"},{"product_id":"sequence-colostrum-400mg-first-milking-rich-in-immune-and-growth-factors-90-capsules","title":"Sequence Colostrum 400mg, First Milking, Rich in Immune and Growth Factors, 90 Capsules","description":"\u003cdiv data-element=\"main\" data-appearance=\"default\" data-content-type=\"html\"\u003e\n\u003ch2\u003eSequence Colostrum 400mg, First Milking, Rich in Immune and Growth Factors, 90 Capsules Details\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eSequence Health Colostrum Capsules 400mg are a supplement for colostrum, the pre-milk fluid produced by all female mammals prior to giving birth, which is truly nature’s perfect immune-enhancing and anti-aging superfood! The capsule is the exact same product as the powder but has been encapsulated in gelatin capsules for ease of transport and dosage.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eSequence Colostrum 400mg, First Milking, Rich in Immune and Growth Factors, 90 Capsules Features and Benefits\u003c\/h3\u003e\n\u003cp\u003eColostrum is truly nature’s perfect immune-enhancing and anti-aging superfood!\u003c\/p\u003e\n\u003cp\u003eThe two main groups of components responsible for the beneficial effects of colostrum are immune factors and growth factors. These powerful, all-natural components work in concert to enhance immune system function and support cellular growth and repair.\u003c\/p\u003e\n\u003cp\u003eAs we age, our bodies gradually produce less and less of these powerful immune and growth factors that help fight disease, repair body tissue and promote energy and vitality. With the decline of these components over time, we age until we eventually die. Colostrum is the only natural source of these life-supporting immune and growth factors!\u003c\/p\u003e\n\u003cp\u003eThe immune factors in colostrum include antibodies that provide immunity from numerous microorganisms. Other immune factors work together to kill bacteria and viruses, regulate the thymus gland, control inflammation, protect against allergic reactions, balance and nourish the immune system.\u003c\/p\u003e\n\u003cp\u003eThe growth factors in colostrum are responsible for rebuilding and repairing cellular tissues. These growth factors also help to build lean muscle, increase at metabolism, improve nutrient uptake, improve memory and mood, increase skin elasticity, balance blood sugar levels and increase energy.\u003c\/p\u003e\n\u003cp\u003eDoes this all sound too good to be true? Few natural supplements have as much medical research supporting its value as colostrum. There are literally thousands of published clinical and scientific research studies proving the health-benefiting properties of colostrum. Here are just a few of the documented benefits of colostrum:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhances overall immune system and helps boost natural resistance to illness and disease\u003c\/li\u003e\n\u003cli\u003eProvides anti-viral, anti-bacterial and anti-fungal protection, creating unfavorable conditions for growth of numerous harmful microorganisms including those responsible for common health problems such as colds, influenza, diarrhea, ulcers, gum disease, and yeast infections\u003c\/li\u003e\n\u003cli\u003eRegulates numerous auto-immune conditions including allergies, asthma, rheumatoid arthritis, lupus, multiple sclerosis, Alzheimer's disease\u003c\/li\u003e\n\u003cli\u003eImproves state of chronic health problems such as diabetes, heart disease, colitis, irritable bowel, leaky gut syndrome, fibromyalgia, chronic fatigue, and HIV\u003c\/li\u003e\n\u003cli\u003eActs as an antioxidant to reduce the damaging effects of free radicals\u003c\/li\u003e\n\u003cli\u003eBinds and transports iron in the body and is beneficial for iron-deficiency anemia\u003c\/li\u003e\n\u003cli\u003eHeals digestive system and enhances nutrient absorption\u003c\/li\u003e\n\u003cli\u003eHelps speed healing of wounds\u003c\/li\u003e\n\u003cli\u003eEnhances lean muscle mass and increases metabolism of body fat\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003e\u003cstrong\u003eWhat is Colostrum?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eLife’s perfect first food, colostrum is the pre-milk fluid produced by all female mammals prior to giving birth.\u003c\/p\u003e\n\u003cp\u003eNaturally rich in immune and growth factors, colostrum helps insure the health of the newborn. We all know newborns fare better when able to obtain colostrum through breastfeeding but did you know that people of all ages can benefit from taking colostrum? Colostrum has applications for every generation and it’s never too late to start receiving the benefits of life’s first food.\u003c\/p\u003e\n\u003cp\u003eSince collecting human colostrum is unrealistic, the next best source is bovine (cow) colostrum as it is nearly identical to that of human’s. In fact, research proves bovine colostrum can enhance immune system function and support growth and repair in all mammals, including humans. In addition, cows produce an abundance of colostrum, more than enough to supply human needs without depriving newborn calves.\u003c\/p\u003e\n\u003cp\u003eHistorically, bovine colostrum has played a significant role in natural healing. In India, Ayurvedic physicians have prescribed it for thousands of years and still do to this day. In Western medicine, bovine colostrum was used extensively for immune purposes prior to the invention of antibiotics and sulfa drugs. In fact, did you know that the Polio vaccine was developed from antibodies isolated from bovine colostrum?\u003c\/p\u003e\n\u003cp\u003eOver the past few years, the scientific community has “rediscovered” this all-natural immune and growth-supporting food. Thousands of clinical and research studies have been published on the use of colostrum and its components to treat a variety of diseases and health concerns.\u003c\/p\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003ch3\u003eProduction of Colostrum\u003c\/h3\u003e\n\u003ch4\u003eSource and Collection\u003c\/h4\u003e\n\u003cp\u003eThe source of colostrum is one of the most important factors to consider when evaluating different brands of colostrum. We encourage everyone to investigate fully the background of any colostrum product before administration.\u003c\/p\u003e\n\u003cp\u003eAt Sequence, our first milking colostrum is obtained only from the finest local, small family dairy herds in North America. Appropriate collection receptacles are supplied to the dairy producers for saving first milking colostrum from healthy cows. This must be the cows' third or subsequent lactation. We only use colostrum collected within the first six hours after birth.\u003cbr\u003e Immediately after milking, the filled jugs are put in the producer's freezer and kept frozen until collection by a representative of our raw materials supplier, or in a few instances, delivered to the company plant by the producer. Colostrum must arrive at the company in a frozen state, unless freshly milked, where it is inspected by trained personnel and placed in a freezer and maintained at -5 degrees F +\/- 5 degrees.\u003c\/p\u003e\n\u003cp\u003eOur raw materials supplier has on file affidavits from each owner\/operator of contributing dairy farms, stating that their animals have not and are not being fed restricted proteins as set out in 21 CFR 589.2000. Each container of colostrum harvested from these dairies has also been recorded as having come from cows not fed illegal feeds.\u003c\/p\u003e\n\u003ch4\u003eProcessing\u003c\/h4\u003e\n\u003cp\u003eProcessing of colostrum is the second most important factor in the quality of colostrum. Our raw materials supplier has developed its own means of processing colostrum and has an FDA approved proprietary pasteurization process that is more effective than standard pasteurization processes at maintaining biological activity. We also homogenize our product for uniformity.\u003cbr\u003e First milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. With the exception of our liquid, all our colostrum products have all naturally occurring fats intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003eThe drying or dessication process is another important factor in maintaining biological activity. Our powder-based products are spray dried at low temperatures by indirect heat using proprietary equipment and processes. We know the length of time in seconds our product is in the drying process and the exact temperature that it reaches in this process. Our first milking colostrum powder maintains virtually all of its original bioavailibility throughout the manufacturing process.\u003c\/p\u003e\n\u003ch4\u003eFinished Products\u003c\/h4\u003e\n\u003cp\u003eFinished products are exactly identified and stored at ambient temperature. Composite samples are evaluated for quality assurance and logged in permanent records. Sequel Natural’s genuine first milking bovine colostrum is produced using proprietary specifications and processes that assure the highest levels of biological activity, guaranteeing the greatest value for your dollar.\u003c\/p\u003e\n\u003ch4\u003eQuality Assurance\u003c\/h4\u003e\n\u003cp\u003eFor your safety and peace of mind, all our colostrum products are made in GMP certified and\/or FDA licensed facilities under the strictest of quality standards. Every batch of product is tested and certified to be free of any harmful pathogens by independent laboratories.\u003c\/p\u003e\n\u003ch3\u003eComponents of Colostrum\u003c\/h3\u003e\n\u003ch4\u003eGrowth Factors\u003c\/h4\u003e\n\u003cp\u003eBovine colostrum is naturally rich in powerful growth factors including Insulin-like growth factor 1 (IGF-1), transforming growth factor (TGF) and epithelial growth factor (EGF). These natural growth factors help slow down the effects of aging on a cellular level, resulting in benefits such as increased energy and vitality, greater lean muscle mass, increased fat metabolism and weight loss, improved memory and elevated mood.\u003c\/p\u003e\n\u003ch4\u003eImmunoglobulins\u003c\/h4\u003e\n\u003cp\u003eImmunoglobulins and antibodies are one and the same. IgA, IgD, IgE, IgG and IgM are the most abundant of the immune factors found in bovine colostrum. IgG neutralizes toxins and microbes in the lymph and circulatory system, IgM destroys bacteria, while IgE and IgD are highly antiviral.\u003c\/p\u003e\n\u003ch4\u003eLactoferrin\u003c\/h4\u003e\n\u003cp\u003eLactoferrin is one of the most powerful antiviral, antibacterial substances, found naturally, in bovine colostrum and human colostrum.\u003c\/p\u003e\n\u003ch4\u003eAdditional Components\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eCytokines\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCytokines are composed of Interleukins that regulate the intensity and duration of immune responses and are responsible for cell-to-cell communications. They boost T-cell activity, regulate lymph activity, stimulate the production of immunoglobulins and elevation of immune activity, and are antiviral and antibacterial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactalbumin\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThese are simple, highly nutritious proteins found in mother's milk and colostrum. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactoperozidase-thiocyanate, plus Peroxidase and Xanthine Oxidase Enzymes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThese have an antimicrobial activity and nonspecific immunity role such as oxidizing (burning up) bacteria by generating the release of hydrogen peroxide. These are the enzymes found in bovine colostrum. Together with hydrogen peroxide and thiocyanate, lactoperoxidase forms a potent natural antibacterial system called the lactoperoxidase system.  Karne J. Losnedahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology Antimicrobial Proteins in Milk, Illinois Dairy Report 1996.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLysozyme\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLysozyme is a powerful hydrolyzing agent, resistant to acids that destroy bacteria and viruses on contact. It is found in perspiration, saliva and tears. In recent years, it has been added to infant formula to boost immune capability. Karen J. Losnehahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology: Antimicrobial Proteins in Milk, Illinois Dairy Report, 1996.\u003c\/p\u003e\n\u003cp\u003eLysozyme kills bacteria by disrupting the formation of a glycosidic bond between the two components of peptoglycon, a constituent of the bacterial cell wall. Lysozyme possesses antibacterial activity against a number of bacteria. This enzyme usually functions in association with Lactoferrin or immunoglobulin A. Lysozyme is effective against Esherichia coli in concert with Immunoglobulin A (IgA).\u003c\/p\u003e\n\u003cp\u003eIt causes lysis of some species of salmonella in association with ascorbate and peroxide. Lysozyme can limit the migration of neutrophils into damaged tissue and might function as an anti-inflammatory agent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProline-Rich Polypeptide\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eProline-rich polypeptide (PRP) is a hormone in colostrum that regulates the thymus gland. PRP is an immunomodulator, meaning it can stimulate an underactive immune system as well as down-regulate an overactive immune system. This makes PRP an especially important component in the fight against autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, and allergies.\u003c\/p\u003e\n\u003ch3\u003eImportance of Natural Fats\u003c\/h3\u003e\n\u003cp\u003eFirst milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. When purchasing colostrum, ensure all its naturally occurring fats are kept intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, most brands of colostrum have most of their fats removed. Removal of the natural fats from colostrum is primarily done for a number of reasons. The main purpose is to artificially elevate the IgG percentage in colostrum, thus making it \"appear\" to be harvested from the first or earlier collections. Another reason is to hide the rancid odor of poor quality, mishandled, or old colostrum. All else being equal, fat-free colostrum is more shelf stable and offers a longer shelf life. Lastly, fat-free colostrum mixes more easily with and dissolves more quickly in water.\u003c\/p\u003e\n\u003cp\u003eExcessive fat is a concern in our diets, as is cholesterol. Genuine first milking colostrum is very low in cholesterol, containing only 1.9 mg of cholesterol per gram of dried colostrum.\u003c\/p\u003e\n\u003ch3\u003eImportance of Oral Delivery\u003c\/h3\u003e\n\u003cp\u003eUsing the proper delivery system is of great importance. The greatest benefits observed in scientific colostrum studies were achieved via oral delivery (absorption in the mouth). Colostrum absorbed in the oral cavity activates the entire body’s immune pathways to open to self-healing.\u003c\/p\u003e\n\u003cp\u003eBecause most infectious microorganisms enter the body through the nose or mouth, the oral cavity is specially designed with mucus membranes and salivary glands that secrete powerful immune components. The oral cavity is loaded with receptor sites which, when activated, alert the entire body through a complex chain reaction of immune system events. To maintain good health, it is critical that we are able to stop pathogens at their initial place of entrance and combat disease-causing organisms in the oral cavity before they travel further.\u003c\/p\u003e\n\u003cp\u003eExamples of oral delivery include taking liquid under the tongue, slowly dissolving a lozenge or eating\/drinking powder mixed with food\/beverage. Swallowing capsules is not an ideal form of delivery as it bypasses the key oral receptor sites and misses the natural protease inhibitors, buffers, mucous secretions, hormones, enzyme, sensors and receptors. Essentially, it is delivered into the stomach without protection of any kind.\u003c\/p\u003e\n\u003cp\u003eThe gelatin capsule is then dissolved and the full effects of the stomach acid are applied to the colostrum components. It then is exposed to the rather basic bile salts in the duodenum and throughout the entire small intestine before it reaches the Gut Associated Lymphoid Tissue (GALT) near our appendix, where the primary response of the capsule ingested colostrum comes about. Much of the colostrum components could now be altered or denatured, and dilute or render them less effective. To compensate, a much larger dose of colostrum would have to be consumed to produce the same effective results. A better alternative would be to open capsules and take the colostrum orally.\u003c\/p\u003e\n\u003cp\u003eLozenges, on the other hand, which are designed to be held inside the mouth for several minutes, are an ideal route for taking colostrum. Why? Because the oral cavity is the gate of entry into the body's communication network.\u003c\/p\u003e\n\u003cp\u003eAs a child, calf, foal, puppy or kitten nurses colostrum floods the oro-nasal pharyngeal cavity exposing the secretion to the many receptor sites. These receptor sights form a variety of communication pathways that distribute signals to various parts of the body. Part of the pharyngeal region contains lymphoid cells, tonsils, referred to as MALT, Mucosal Associated Lymphoid Tissue. This is the same type of tissue as the lymphoid tissue near the illio-cecal valve termed as GALT.\u003c\/p\u003e\n\u003cp\u003eThe great advantage of MALT over GALT is that MALT is present early on, before any digestive processes start to alter the colostral components as in GALT. MALT is also protected by many of the buffers, enzymes, mucous and other protective properies so secreted by glands in the oro-naso pharyngeal lamina propria.\u003c\/p\u003e\n\u003cp\u003eImportance of First Milking\u003cbr\u003e While sometimes called “first milk”, colostrum is actually a pre-milk substance since milk is produced after colostrum. Birth is the event that stops colostrum production and triggers the creation of milk. All else being equal, the sooner after birth colostrum is collected, the higher its quality (measured as percentage of protein) and corresponding levels of immune and growth factors.\u003c\/p\u003e\n\u003cp\u003eThe highest quality colostrum is usually collected within the first six hours after birth. This is referred to as first milking colostrum and it is the closest thing to pure colostrum, which is only available immediately after birth. Colostrum from subsequent milkings, if blended with the first, compromises the delicate balance of immune and growth factors found only in first milking colostrum.\u003c\/p\u003e\n\u003cp\u003eOnly first-milking colostrum is ever used in clinical and scientific research studies as colostrum quality declines rapidly after birth. Colostrum harvested twelve hours after birth contains only about one-third of the immune and growth factors present at birth and after twenty-four hours, it is less than one-quarter of its original quality.\u003c\/p\u003e\n\u003cp\u003eAs little as 125mg of genuine, first-milking colostrum delivered via the oral cavity is sufficient to trigger an immune response. Several times that amount may be required with conventional multiple-milking products. Most colostrum products on the market are a combination of the first five milkings, collected up to 48 hours after birth.\u003c\/p\u003e\n\u003cp\u003eThe following table shows how quickly the quality of colostrum declines after birth:\u003c\/p\u003e\n\u003cp\u003e\u003cimg style=\"width: 379px; height: 202px;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequence-colostrum-quality-declines-after-birth.jpg\" alt=\"Sequence Colostrum 200mg, 90 Lozenges\"\u003e\u003c\/p\u003e\n\u003cp\u003eAs you can see, time of harvest is of key importance in determining the quality of colostrum. If a product does not claim its source to be from only the first milking, likely it is not. Or, if it cannot back up its claims to be from only the first milking with a certificate of analysis done by an independent laboratory, it is likely not true first milking colostrum.\u003c\/p\u003e\n\u003cp\u003eGenuine first milking colostrum can cost several times as much as colostrum taken from a combination of subsequent milkings. Keep in mind that only the highest quality, first-milking colostrum is used in the thousands of clinical and scientific research studies. Colostrum collected from multiple milkings may not provide the desired results.\u003c\/p\u003e\n\u003ch3\u003eScientific Definition of Colostrum\u003c\/h3\u003e\n\u003cp\u003eColostrum is the first lacteal secretion produced by the mammary glands of mammals at the beginning of lactation and is intended for ingestion by the newborn during the first hours of life. In most mammals, such as humans, many of the biologically active substances essential to development and survival, such as growth promoting substances and immunoglobulins, cross the placental barrier and are transferred to the fetus in utero. In sharp contrast, in bovine essentially none of these biologically active substances cross the placental barrier and, thus, must be acquired by the calf through suckling during the early hours of its life. As such, bovine colostrum represents a unique, concentrated resource for a wide variety of biologically active substances.\u003c\/p\u003e\n\u003cp\u003eColostrogenesis, the formation of colostrum, and lactogenesis, the process which mammary tissue undergoes when changing from a non-lactating to a lactating state, are events associated with pregnancy that are controlled by a specific complex of hormones and influenced by physical factors associated with the mammary gland. In the cow, development of mammary tissue and its ability to synthesize and produce secretions is promoted primarily by growth hormone and its mediators, the insulin-like growth factors IGF-1 and IGF-2 and the transforming growth factors TGF-beta 1 and TGF-beta 2. The process is regulated by a series of other hormones, one of the most important being progesterone, which attaches to special receptors on the cells lining the mammary gland and prevents them from secreting any fluids into the gland during most of pregnancy.\u003c\/p\u003e\n\u003cp\u003eThe formation of colostrum in the pregnant cow is initiated about 3-4 weeks before parturition (birth) when a limited amount of fluid is released into the developing mammary tissue containing small amounts of the growth factors and other transforming substances. These substances influence the appearance of specific receptors on the surface of the cells lining the mammary gland that will facilitate the transfer of materials from the mother's blood into the gland. The substances include, among others, the IgG (antibodies) necessary to convey passive immunity to the calf and various hormones and growth promoters required to induce development of the newborn calf.\u003c\/p\u003e\n\u003cp\u003eAbout two weeks before birth, the receptors for IgG become fully active. IgG from the mother's blood attaches to the receptors and is transferred via special vessels through the cells into the fluid in the gland. The IgM and IgA found in colostrum are actually produced by cells (B cells) from the mother's immune system that have moved into the mammary tissue. These molecules are transferred into the fluid in the gland by a similar receptor mechanism. The additional receptors on the cells lining the mammary gland capable of transporting other substances become fully activated about 3-5 days before birth.\u003c\/p\u003e\n\u003cp\u003eAbout 2 days before birth, the hormonal balance begins to shift when the mother's blood concentration of prolactin and glucocorticoid hormones increases sharply, overriding some of the inhibitory effects of progesterone. This initiates the production of copious secretions and switches on the ability of cells in the mammary tissue to synthesize various substances, including lactose.\u003c\/p\u003e\n\u003cp\u003eAt birth, when the placenta is eliminated, progesterone levels fall dramatically in the mother and its inhibitory control of the secretions is removed. Simultaneously, a protein-based substance develops in the cells lining the mammary gland that essentially blocks any further transfer of substances from the mother's blood into the gland.\u003c\/p\u003e\n\u003cp\u003eThe composition of the fluid in the mammary gland at birth is that of true colostrum and reflects the functional changes that have occurred in the gland up to that time; it a) has a high protein concentration, most of which is IgG; b) contains the highest concentration of growth promoters, other hormones and additional metabolically active substances; c) is low in lactose content; and d) is rich in milk fat.\u003c\/p\u003e\n\u003cp\u003eIn addition to containing a high concentration of maternally-derived immunoglobulins, first milking bovine colostrum contains a number of other biologically active substances. Although all of these substances have not as yet been characterized, many of the seemingly most important ones have been identified, including, among others, the following:\u003c\/p\u003e\n\u003cp\u003eInsulin-like growth factors that act on various metabolic processes that affect the uptake of glucose to derive a source of energy and utilization of amino acids to build proteins by cells in the body.\u003cbr\u003e Subunits of the hormone thymosin that act independently and in concert on the thymus gland to stimulate development and activation of the immune system.\u003cbr\u003e Cytokines that stimulate the development and activation of various cells associated with the immune system.\u003cbr\u003e Lactoferrin and transferrin, which are proteins that bind iron and act primarily in the gut to impede the growth of certain potentially pathogenic aerobic bacteria, like E. coli.\u003cbr\u003e Xanthine oxidase and lactoperoxidase, which are enzymes that can inhibit the growth of certain potentially pathogenic bacteria in the gut.\u003c\/p\u003e\n\u003cp\u003eAfter birth, one of the most influential factors on the composition of subsequent secretions is physical removal of the fluid from the mammary gland. The removal of even small quantities of fluid triggers the production of copious amounts of secretion from the cells in the mammary gland.\u003c\/p\u003e\n\u003cp\u003eSince the transfer of biologically-active substances from the mother's blood is blocked, replacement fluid will contain primarily substances synthesized by cells in the mammary gland and, thus, will be of a different composition than the fluid originally contained in the mammary gland at birth. This fluid is known as transitional milk. The more original fluid, which is true colostrum, that is removed, the more adulterated the residual fluid becomes with transitional milk.\u003c\/p\u003e\n\u003cp\u003eThis becomes more complex since the mother's system will begin to reabsorb certain of the biologically-active substances, including some of the hormones and the immunoglobulins, from the mammary gland back into her bloodstream within 6-8 hours after birth of her calf. Therefore, the composition of the mammary secretions changes rapidly during the hours and days after birth so that there is a continuous transition from true colostrum to mature milk.\u003c\/p\u003e\n\u003cp\u003eThe average yield of colostrum taken from a mature Holstein dairy cow during the first six hours after birth will be approximately ten liters. This removes about 80% of the true colostrum while the remaining 20% usually cannot be milked out during this period due to the normal congestion of the udder of the mother. After removal of the first harvest, the udder quickly fills with \"transitional milk\", which is lower in fat and protein and higher in lactose.\u003c\/p\u003e\n\u003cp\u003eThe milking taken during the 6-12 hour period after birth again removes about 80% of the lacteal secretions present in the udder, including the 20% residual from the first milking. Again, 20% of this \"colostral\" material remains and is further diluted as the udder refills with \"transitional milk\". The only unadulterated true colostrum is, therefore, derived upon harvesting the first milking from the mother within six hours after birth and before the calf has suckled.\u003c\/p\u003e\n\u003cp\u003eTo assure that calves receive sufficient quantities of high quality true colostrum, most dairy producers in the United States do not allow the calf to suckle its mother immediately after birth, but prefer to physically remove the true colostrum, and feed the required amount by nursing bottle. The remainder of this material is what is then used to make colostrum products for human consumption.\u003c\/p\u003e\n\u003ch3\u003eWhat Doctors are Saying\u003c\/h3\u003e\n\u003cp\u003e“Antibodies in bovine colostrum are able to neutralize the most harmful bacteria, viruses, and yeasts.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Brandtzaeg; Annals of the New York Academy of Sciences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Immunoglobulin in colostrum has been used to successfully treat: Thrombocytopenia, Anemia, Neutropenia, Myasthenia Gravis, Guillain Barre, Multiple Sclerosis, Systemic Lupus, Rheumatoid Arthritis, Bullous Pemphigoid, Kawasaki’s Syndrome, Chronic Fatigue, Crohn’s disease, among others.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Dwyer; New England Journal of Medicine\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Insulin-like Growth Factor 1 (IGF-1), found in bovine colostrum, stimulates bone and muscle growth and nerve regeneration. Also found: topical administration to wounds resulted in more effective healing.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Skottne, et al; Paediatric Scandinavia, Sweden\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Clinical studies show that immunoglobulin found in bovine colostrum, may be responsible for regulating allergic response.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Tortora, et al; Microbiology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Proline Rich Polypeptide (PRP) in bovine colostrum has the same ability to regulate activity of the immune system as hor- mones of the Thymus gland. It activates an underactive immune system and also suppresses an overactive immune system, such as is often seen in the autoimmune diseases.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Staroscik, et al; Molecular Immunology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Colostrum contains significant amounts of Interlukin-10 (a strong inflammation inhibitory agent), found significant in reduc- ing inflammation in arthritic joints and injury areas.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Olle Hernell, Univ. of Ulmea, Sweden; Science\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Lactoferrin, a glycoprotein in colostrum, can bind free iron with high affinity and thus function as a local antioxidant, protecting immune cells against free radicals.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Britigan, et al; Advances in Experimental Medicine and Biology\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Sequence","offers":[{"title":"Default Title","offer_id":43007179620523,"sku":"SEQ00105","price":38.97,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequence-colostrum-90-capsules.jpg?v=1710970200"},{"product_id":"sequence-colostrum-200mg-first-milking-rich-in-immune-and-growth-factors-50g","title":"Sequence Colostrum Powder 200mg, First Milking, Rich in Immune and Growth Factors, 50g","description":"\u003cdiv data-content-type=\"html\" data-appearance=\"default\" data-element=\"main\"\u003e\n\u003ch2\u003eSequence Colostrum Powder 200mg, First Milking, Rich in Immune and Growth Factors Details\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eAn effective anti-aging and performance-enhancing product, our colostrum powder is incredibly versatile. It can be mixed into foods or drinks (think yogurt, applesauce, oatmeal, or a protein shake) or even applied topically to aid in the faster healing of cuts, abrasions, and minor skin and gum irritations. \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFor topical use, mix powder with a little water to make a thick paste and apply to the affected area. Let dry to form a protective barrier. Reapply every few hours as required.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\n\u003cspan style=\"font-size: 0.875rem;\"\u003eSequence Colostrum 200mg, First Milking, Rich in Immune and Growth Factors, 50g \u003c\/span\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003eFeatures and Benefits\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003cp\u003eColostrum is truly nature’s perfect immune-enhancing and anti-aging superfood!\u003c\/p\u003e\n\u003cp\u003eThe two main groups of components responsible for the beneficial effects of colostrum are immune factors and growth factors. These powerful, all-natural components work in concert to enhance immune system function and support cellular growth and repair.\u003c\/p\u003e\n\u003cp\u003eAs we age, our bodies gradually produce less and less of these powerful immune and growth factors that help fight disease, repair body tissue and promote energy and vitality. With the decline of these components over time, we age until we eventually die. Colostrum is the only natural source of these life-supporting immune and growth factors!\u003c\/p\u003e\n\u003cp\u003eThe immune factors in colostrum include antibodies that provide immunity from numerous microorganisms. Other immune factors work together to kill bacteria and viruses, regulate the thymus gland, control inflammation, protect against allergic reactions, balance and nourish the immune system.\u003c\/p\u003e\n\u003cp\u003eThe growth factors in colostrum are responsible for rebuilding and repairing cellular tissues. These growth factors also help to build lean muscle, increase at metabolism, improve nutrient uptake, improve memory and mood, increase skin elasticity, balance blood sugar levels and increase energy.\u003c\/p\u003e\n\u003cp\u003eDoes this all sound too good to be true? Few natural supplements have as much medical research supporting its value as colostrum. There are literally thousands of published clinical and scientific research studies proving the health-benefiting properties of colostrum. Here are just a few of the documented benefits of colostrum:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhances overall immune system and helps boost natural resistance to illness and disease\u003c\/li\u003e\n\u003cli\u003eProvides anti-viral, anti-bacterial and anti-fungal protection, creating unfavorable conditions for growth of numerous harmful microorganisms including those responsible for common health problems such as colds, influenza, diarrhea, ulcers, gum disease, and yeast infections\u003c\/li\u003e\n\u003cli\u003eRegulates numerous auto-immune conditions including allergies, asthma, rheumatoid arthritis, lupus, multiple sclerosis, Alzheimer's disease\u003c\/li\u003e\n\u003cli\u003eImproves state of chronic health problems such as diabetes, heart disease, colitis, irritable bowel, leaky gut syndrome, fibromyalgia, chronic fatigue, and HIV\u003c\/li\u003e\n\u003cli\u003eActs as an antioxidant to reduce the damaging effects of free radicals\u003c\/li\u003e\n\u003cli\u003eBinds and transports iron in the body and is beneficial for iron-deficiency anemia\u003c\/li\u003e\n\u003cli\u003eHeals digestive system and enhances nutrient absorption\u003c\/li\u003e\n\u003cli\u003eHelps speed healing of wounds\u003c\/li\u003e\n\u003cli\u003eEnhances lean muscle mass and increases metabolism of body fat\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003e\u003cstrong\u003eWhat is Colostrum?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eLife’s perfect first food, colostrum is the pre-milk fluid produced by all female mammals prior to giving birth.\u003c\/p\u003e\n\u003cp\u003eNaturally rich in immune and growth factors, colostrum helps insure the health of the newborn. We all know newborns fare better when able to obtain colostrum through breastfeeding but did you know that people of all ages can benefit from taking colostrum? Colostrum has applications for every generation and it’s never too late to start receiving the benefits of life’s first food.\u003c\/p\u003e\n\u003cp\u003eSince collecting human colostrum is unrealistic, the next best source is bovine (cow) colostrum as it is nearly identical to that of human’s. In fact, research proves bovine colostrum can enhance immune system function and support growth and repair in all mammals, including humans. In addition, cows produce an abundance of colostrum, more than enough to supply human needs without depriving newborn calves.\u003c\/p\u003e\n\u003cp\u003eHistorically, bovine colostrum has played a significant role in natural healing. In India, Ayurvedic physicians have prescribed it for thousands of years and still do to this day. In Western medicine, bovine colostrum was used extensively for immune purposes prior to the invention of antibiotics and sulfa drugs. In fact, did you know that the Polio vaccine was developed from antibodies isolated from bovine colostrum?\u003c\/p\u003e\n\u003cp\u003eOver the past few years, the scientific community has “rediscovered” this all-natural immune and growth-supporting food. Thousands of clinical and research studies have been published on the use of colostrum and its components to treat a variety of diseases and health concerns.\u003c\/p\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003ch3\u003eProduction of Colostrum\u003c\/h3\u003e\n\u003ch4\u003eSource and Collection\u003c\/h4\u003e\n\u003cp\u003eThe source of colostrum is one of the most important factors to consider when evaluating different brands of colostrum. We encourage everyone to investigate fully the background of any colostrum product before administration.\u003c\/p\u003e\n\u003cp\u003eAt Sequence, our first milking colostrum is obtained only from the finest local, small family dairy herds in North America. Appropriate collection receptacles are supplied to the dairy producers for saving first milking colostrum from healthy cows. This must be the cows' third or subsequent lactation. We only use colostrum collected within the first six hours after birth.\u003cbr\u003eImmediately after milking, the filled jugs are put in the producer's freezer and kept frozen until collection by a representative of our raw materials supplier, or in a few instances, delivered to the company plant by the producer. Colostrum must arrive at the company in a frozen state, unless freshly milked, where it is inspected by trained personnel and placed in a freezer and maintained at -5 degrees F +\/- 5 degrees.\u003c\/p\u003e\n\u003cp\u003eOur raw materials supplier has on file affidavits from each owner\/operator of contributing dairy farms, stating that their animals have not and are not being fed restricted proteins as set out in 21 CFR 589.2000. Each container of colostrum harvested from these dairies has also been recorded as having come from cows not fed illegal feeds.\u003c\/p\u003e\n\u003ch4\u003eProcessing\u003c\/h4\u003e\n\u003cp\u003eProcessing of colostrum is the second most important factor in the quality of colostrum. Our raw materials supplier has developed its own means of processing colostrum and has an FDA approved proprietary pasteurization process that is more effective than standard pasteurization processes at maintaining biological activity. We also homogenize our product for uniformity.\u003cbr\u003eFirst milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. With the exception of our liquid, all our colostrum products have all naturally occurring fats intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003eThe drying or dessication process is another important factor in maintaining biological activity. Our powder-based products are spray dried at low temperatures by indirect heat using proprietary equipment and processes. We know the length of time in seconds our product is in the drying process and the exact temperature that it reaches in this process. Our first milking colostrum powder maintains virtually all of its original bioavailibility throughout the manufacturing process.\u003c\/p\u003e\n\u003ch4\u003eFinished Products\u003c\/h4\u003e\n\u003cp\u003eFinished products are exactly identified and stored at ambient temperature. Composite samples are evaluated for quality assurance and logged in permanent records. Sequel Natural’s genuine first milking bovine colostrum is produced using proprietary specifications and processes that assure the highest levels of biological activity, guaranteeing the greatest value for your dollar.\u003c\/p\u003e\n\u003ch4\u003eQuality Assurance\u003c\/h4\u003e\n\u003cp\u003eFor your safety and peace of mind, all our colostrum products are made in GMP certified and\/or FDA licensed facilities under the strictest of quality standards. Every batch of product is tested and certified to be free of any harmful pathogens by independent laboratories.\u003c\/p\u003e\n\u003ch3\u003eComponents of Colostrum\u003c\/h3\u003e\n\u003ch4\u003eGrowth Factors\u003c\/h4\u003e\n\u003cp\u003eBovine colostrum is naturally rich in powerful growth factors including Insulin-like growth factor 1 (IGF-1), transforming growth factor (TGF) and epithelial growth factor (EGF). These natural growth factors help slow down the effects of aging on a cellular level, resulting in benefits such as increased energy and vitality, greater lean muscle mass, increased fat metabolism and weight loss, improved memory and elevated mood.\u003c\/p\u003e\n\u003ch4\u003eImmunoglobulins\u003c\/h4\u003e\n\u003cp\u003eImmunoglobulins and antibodies are one and the same. IgA, IgD, IgE, IgG and IgM are the most abundant of the immune factors found in bovine colostrum. IgG neutralizes toxins and microbes in the lymph and circulatory system, IgM destroys bacteria, while IgE and IgD are highly antiviral.\u003c\/p\u003e\n\u003ch4\u003eLactoferrin\u003c\/h4\u003e\n\u003cp\u003eLactoferrin is one of the most powerful antiviral, antibacterial substances, found naturally, in bovine colostrum and human colostrum.\u003c\/p\u003e\n\u003ch4\u003eAdditional Components\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eCytokines\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCytokines are composed of Interleukins that regulate the intensity and duration of immune responses and are responsible for cell-to-cell communications. They boost T-cell activity, regulate lymph activity, stimulate the production of immunoglobulins and elevation of immune activity, and are antiviral and antibacterial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactalbumin\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThese are simple, highly nutritious proteins found in mother's milk and colostrum. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactoperozidase-thiocyanate, plus Peroxidase and Xanthine Oxidase Enzymes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThese have an antimicrobial activity and nonspecific immunity role such as oxidizing (burning up) bacteria by generating the release of hydrogen peroxide. These are the enzymes found in bovine colostrum. Together with hydrogen peroxide and thiocyanate, lactoperoxidase forms a potent natural antibacterial system called the lactoperoxidase system.  Karne J. Losnedahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology Antimicrobial Proteins in Milk, Illinois Dairy Report 1996.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLysozyme\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLysozyme is a powerful hydrolyzing agent, resistant to acids that destroy bacteria and viruses on contact. It is found in perspiration, saliva and tears. In recent years, it has been added to infant formula to boost immune capability. Karen J. Losnehahl, Hong Wang, Mueen Aslam, Zou Sixiang, and Walter L. Hurley, Lactation Biology: Antimicrobial Proteins in Milk, Illinois Dairy Report, 1996.\u003c\/p\u003e\n\u003cp\u003eLysozyme kills bacteria by disrupting the formation of a glycosidic bond between the two components of peptoglycon, a constituent of the bacterial cell wall. Lysozyme possesses antibacterial activity against a number of bacteria. This enzyme usually functions in association with Lactoferrin or immunoglobulin A. Lysozyme is effective against Esherichia coli in concert with Immunoglobulin A (IgA).\u003c\/p\u003e\n\u003cp\u003eIt causes lysis of some species of salmonella in association with ascorbate and peroxide. Lysozyme can limit the migration of neutrophils into damaged tissue and might function as an anti-inflammatory agent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProline-Rich Polypeptide\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eProline-rich polypeptide (PRP) is a hormone in colostrum that regulates the thymus gland. PRP is an immunomodulator, meaning it can stimulate an underactive immune system as well as down-regulate an overactive immune system. This makes PRP an especially important component in the fight against autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, and allergies.\u003c\/p\u003e\n\u003ch3\u003eImportance of Natural Fats\u003c\/h3\u003e\n\u003cp\u003eFirst milking colostrum is naturally rich in fats, making up about 20-25% of total solids. Fats serve as the critical transporter (or surrogate) for the the powerful growth factor IGF-1. When purchasing colostrum, ensure all its naturally occurring fats are kept intact for the greatest anti-aging benefits.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, most brands of colostrum have most of their fats removed. Removal of the natural fats from colostrum is primarily done for a number of reasons. The main purpose is to artificially elevate the IgG percentage in colostrum, thus making it \"appear\" to be harvested from the first or earlier collections. Another reason is to hide the rancid odor of poor quality, mishandled, or old colostrum. All else being equal, fat-free colostrum is more shelf stable and offers a longer shelf life. Lastly, fat-free colostrum mixes more easily with and dissolves more quickly in water.\u003c\/p\u003e\n\u003cp\u003eExcessive fat is a concern in our diets, as is cholesterol. Genuine first milking colostrum is very low in cholesterol, containing only 1.9 mg of cholesterol per gram of dried colostrum.\u003c\/p\u003e\n\u003ch3\u003eImportance of Oral Delivery\u003c\/h3\u003e\n\u003cp\u003eUsing the proper delivery system is of great importance. The greatest benefits observed in scientific colostrum studies were achieved via oral delivery (absorption in the mouth). Colostrum absorbed in the oral cavity activates the entire body’s immune pathways to open to self-healing.\u003c\/p\u003e\n\u003cp\u003eBecause most infectious microorganisms enter the body through the nose or mouth, the oral cavity is specially designed with mucus membranes and salivary glands that secrete powerful immune components. The oral cavity is loaded with receptor sites which, when activated, alert the entire body through a complex chain reaction of immune system events. To maintain good health, it is critical that we are able to stop pathogens at their initial place of entrance and combat disease-causing organisms in the oral cavity before they travel further.\u003c\/p\u003e\n\u003cp\u003eExamples of oral delivery include taking liquid under the tongue, slowly dissolving a lozenge or eating\/drinking powder mixed with food\/beverage. Swallowing capsules is not an ideal form of delivery as it bypasses the key oral receptor sites and misses the natural protease inhibitors, buffers, mucous secretions, hormones, enzyme, sensors and receptors. Essentially, it is delivered into the stomach without protection of any kind.\u003c\/p\u003e\n\u003cp\u003eThe gelatin capsule is then dissolved and the full effects of the stomach acid are applied to the colostrum components. It then is exposed to the rather basic bile salts in the duodenum and throughout the entire small intestine before it reaches the Gut Associated Lymphoid Tissue (GALT) near our appendix, where the primary response of the capsule ingested colostrum comes about. Much of the colostrum components could now be altered or denatured, and dilute or render them less effective. To compensate, a much larger dose of colostrum would have to be consumed to produce the same effective results. A better alternative would be to open capsules and take the colostrum orally.\u003c\/p\u003e\n\u003cp\u003eLozenges, on the other hand, which are designed to be held inside the mouth for several minutes, are an ideal route for taking colostrum. Why? Because the oral cavity is the gate of entry into the body's communication network.\u003c\/p\u003e\n\u003cp\u003eAs a child, calf, foal, puppy or kitten nurses colostrum floods the oro-nasal pharyngeal cavity exposing the secretion to the many receptor sites. These receptor sights form a variety of communication pathways that distribute signals to various parts of the body. Part of the pharyngeal region contains lymphoid cells, tonsils, referred to as MALT, Mucosal Associated Lymphoid Tissue. This is the same type of tissue as the lymphoid tissue near the illio-cecal valve termed as GALT.\u003c\/p\u003e\n\u003cp\u003eThe great advantage of MALT over GALT is that MALT is present early on, before any digestive processes start to alter the colostral components as in GALT. MALT is also protected by many of the buffers, enzymes, mucous and other protective properies so secreted by glands in the oro-naso pharyngeal lamina propria.\u003c\/p\u003e\n\u003cp\u003eImportance of First Milking\u003cbr\u003eWhile sometimes called “first milk”, colostrum is actually a pre-milk substance since milk is produced after colostrum. Birth is the event that stops colostrum production and triggers the creation of milk. All else being equal, the sooner after birth colostrum is collected, the higher its quality (measured as percentage of protein) and corresponding levels of immune and growth factors.\u003c\/p\u003e\n\u003cp\u003eThe highest quality colostrum is usually collected within the first six hours after birth. This is referred to as first milking colostrum and it is the closest thing to pure colostrum, which is only available immediately after birth. Colostrum from subsequent milkings, if blended with the first, compromises the delicate balance of immune and growth factors found only in first milking colostrum.\u003c\/p\u003e\n\u003cp\u003eOnly first-milking colostrum is ever used in clinical and scientific research studies as colostrum quality declines rapidly after birth. Colostrum harvested twelve hours after birth contains only about one-third of the immune and growth factors present at birth and after twenty-four hours, it is less than one-quarter of its original quality.\u003c\/p\u003e\n\u003cp\u003eAs little as 125mg of genuine, first-milking colostrum delivered via the oral cavity is sufficient to trigger an immune response. Several times that amount may be required with conventional multiple-milking products. Most colostrum products on the market are a combination of the first five milkings, collected up to 48 hours after birth.\u003c\/p\u003e\n\u003cp\u003eThe following table shows how quickly the quality of colostrum declines after birth:\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Sequence Colostrum 200mg, 90 Lozenges\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequence-colostrum-quality-declines-after-birth.jpg\" style=\"width: 379px; height: 202px;\"\u003e\u003c\/p\u003e\n\u003cp\u003eAs you can see, time of harvest is of key importance in determining the quality of colostrum. If a product does not claim its source to be from only the first milking, likely it is not. Or, if it cannot back up its claims to be from only the first milking with a certificate of analysis done by an independent laboratory, it is likely not true first milking colostrum.\u003c\/p\u003e\n\u003cp\u003eGenuine first milking colostrum can cost several times as much as colostrum taken from a combination of subsequent milkings. Keep in mind that only the highest quality, first-milking colostrum is used in the thousands of clinical and scientific research studies. Colostrum collected from multiple milkings may not provide the desired results.\u003c\/p\u003e\n\u003ch3\u003eScientific Definition of Colostrum\u003c\/h3\u003e\n\u003cp\u003eColostrum is the first lacteal secretion produced by the mammary glands of mammals at the beginning of lactation and is intended for ingestion by the newborn during the first hours of life. In most mammals, such as humans, many of the biologically active substances essential to development and survival, such as growth promoting substances and immunoglobulins, cross the placental barrier and are transferred to the fetus in utero. In sharp contrast, in bovine essentially none of these biologically active substances cross the placental barrier and, thus, must be acquired by the calf through suckling during the early hours of its life. As such, bovine colostrum represents a unique, concentrated resource for a wide variety of biologically active substances.\u003c\/p\u003e\n\u003cp\u003eColostrogenesis, the formation of colostrum, and lactogenesis, the process which mammary tissue undergoes when changing from a non-lactating to a lactating state, are events associated with pregnancy that are controlled by a specific complex of hormones and influenced by physical factors associated with the mammary gland. In the cow, development of mammary tissue and its ability to synthesize and produce secretions is promoted primarily by growth hormone and its mediators, the insulin-like growth factors IGF-1 and IGF-2 and the transforming growth factors TGF-beta 1 and TGF-beta 2. The process is regulated by a series of other hormones, one of the most important being progesterone, which attaches to special receptors on the cells lining the mammary gland and prevents them from secreting any fluids into the gland during most of pregnancy.\u003c\/p\u003e\n\u003cp\u003eThe formation of colostrum in the pregnant cow is initiated about 3-4 weeks before parturition (birth) when a limited amount of fluid is released into the developing mammary tissue containing small amounts of the growth factors and other transforming substances. These substances influence the appearance of specific receptors on the surface of the cells lining the mammary gland that will facilitate the transfer of materials from the mother's blood into the gland. The substances include, among others, the IgG (antibodies) necessary to convey passive immunity to the calf and various hormones and growth promoters required to induce development of the newborn calf.\u003c\/p\u003e\n\u003cp\u003eAbout two weeks before birth, the receptors for IgG become fully active. IgG from the mother's blood attaches to the receptors and is transferred via special vessels through the cells into the fluid in the gland. The IgM and IgA found in colostrum are actually produced by cells (B cells) from the mother's immune system that have moved into the mammary tissue. These molecules are transferred into the fluid in the gland by a similar receptor mechanism. The additional receptors on the cells lining the mammary gland capable of transporting other substances become fully activated about 3-5 days before birth.\u003c\/p\u003e\n\u003cp\u003eAbout 2 days before birth, the hormonal balance begins to shift when the mother's blood concentration of prolactin and glucocorticoid hormones increases sharply, overriding some of the inhibitory effects of progesterone. This initiates the production of copious secretions and switches on the ability of cells in the mammary tissue to synthesize various substances, including lactose.\u003c\/p\u003e\n\u003cp\u003eAt birth, when the placenta is eliminated, progesterone levels fall dramatically in the mother and its inhibitory control of the secretions is removed. Simultaneously, a protein-based substance develops in the cells lining the mammary gland that essentially blocks any further transfer of substances from the mother's blood into the gland.\u003c\/p\u003e\n\u003cp\u003eThe composition of the fluid in the mammary gland at birth is that of true colostrum and reflects the functional changes that have occurred in the gland up to that time; it a) has a high protein concentration, most of which is IgG; b) contains the highest concentration of growth promoters, other hormones and additional metabolically active substances; c) is low in lactose content; and d) is rich in milk fat.\u003c\/p\u003e\n\u003cp\u003eIn addition to containing a high concentration of maternally-derived immunoglobulins, first milking bovine colostrum contains a number of other biologically active substances. Although all of these substances have not as yet been characterized, many of the seemingly most important ones have been identified, including, among others, the following:\u003c\/p\u003e\n\u003cp\u003eInsulin-like growth factors that act on various metabolic processes that affect the uptake of glucose to derive a source of energy and utilization of amino acids to build proteins by cells in the body.\u003cbr\u003eSubunits of the hormone thymosin that act independently and in concert on the thymus gland to stimulate development and activation of the immune system.\u003cbr\u003eCytokines that stimulate the development and activation of various cells associated with the immune system.\u003cbr\u003eLactoferrin and transferrin, which are proteins that bind iron and act primarily in the gut to impede the growth of certain potentially pathogenic aerobic bacteria, like E. coli.\u003cbr\u003eXanthine oxidase and lactoperoxidase, which are enzymes that can inhibit the growth of certain potentially pathogenic bacteria in the gut.\u003c\/p\u003e\n\u003cp\u003eAfter birth, one of the most influential factors on the composition of subsequent secretions is physical removal of the fluid from the mammary gland. The removal of even small quantities of fluid triggers the production of copious amounts of secretion from the cells in the mammary gland.\u003c\/p\u003e\n\u003cp\u003eSince the transfer of biologically-active substances from the mother's blood is blocked, replacement fluid will contain primarily substances synthesized by cells in the mammary gland and, thus, will be of a different composition than the fluid originally contained in the mammary gland at birth. This fluid is known as transitional milk. The more original fluid, which is true colostrum, that is removed, the more adulterated the residual fluid becomes with transitional milk.\u003c\/p\u003e\n\u003cp\u003eThis becomes more complex since the mother's system will begin to reabsorb certain of the biologically-active substances, including some of the hormones and the immunoglobulins, from the mammary gland back into her bloodstream within 6-8 hours after birth of her calf. Therefore, the composition of the mammary secretions changes rapidly during the hours and days after birth so that there is a continuous transition from true colostrum to mature milk.\u003c\/p\u003e\n\u003cp\u003eThe average yield of colostrum taken from a mature Holstein dairy cow during the first six hours after birth will be approximately ten liters. This removes about 80% of the true colostrum while the remaining 20% usually cannot be milked out during this period due to the normal congestion of the udder of the mother. After removal of the first harvest, the udder quickly fills with \"transitional milk\", which is lower in fat and protein and higher in lactose.\u003c\/p\u003e\n\u003cp\u003eThe milking taken during the 6-12 hour period after birth again removes about 80% of the lacteal secretions present in the udder, including the 20% residual from the first milking. Again, 20% of this \"colostral\" material remains and is further diluted as the udder refills with \"transitional milk\". The only unadulterated true colostrum is, therefore, derived upon harvesting the first milking from the mother within six hours after birth and before the calf has suckled.\u003c\/p\u003e\n\u003cp\u003eTo assure that calves receive sufficient quantities of high quality true colostrum, most dairy producers in the United States do not allow the calf to suckle its mother immediately after birth, but prefer to physically remove the true colostrum, and feed the required amount by nursing bottle. The remainder of this material is what is then used to make colostrum products for human consumption.\u003c\/p\u003e\n\u003ch3\u003eWhat Doctors are Saying\u003c\/h3\u003e\n\u003cp\u003e“Antibodies in bovine colostrum are able to neutralize the most harmful bacteria, viruses, and yeasts.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Brandtzaeg; Annals of the New York Academy of Sciences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Immunoglobulin in colostrum has been used to successfully treat: Thrombocytopenia, Anemia, Neutropenia, Myasthenia Gravis, Guillain Barre, Multiple Sclerosis, Systemic Lupus, Rheumatoid Arthritis, Bullous Pemphigoid, Kawasaki’s Syndrome, Chronic Fatigue, Crohn’s disease, among others.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Dwyer; New England Journal of Medicine\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Insulin-like Growth Factor 1 (IGF-1), found in bovine colostrum, stimulates bone and muscle growth and nerve regeneration. Also found: topical administration to wounds resulted in more effective healing.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Skottne, et al; Paediatric Scandinavia, Sweden\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Clinical studies show that immunoglobulin found in bovine colostrum, may be responsible for regulating allergic response.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Tortora, et al; Microbiology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Proline Rich Polypeptide (PRP) in bovine colostrum has the same ability to regulate activity of the immune system as hor- mones of the Thymus gland. It activates an underactive immune system and also suppresses an overactive immune system, such as is often seen in the autoimmune diseases.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDrs. Staroscik, et al; Molecular Immunology\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Colostrum contains significant amounts of Interlukin-10 (a strong inflammation inhibitory agent), found significant in reduc- ing inflammation in arthritic joints and injury areas.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Olle Hernell, Univ. of Ulmea, Sweden; Science\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e“Lactoferrin, a glycoprotein in colostrum, can bind free iron with high affinity and thus function as a local antioxidant, protecting immune cells against free radicals.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10px;\"\u003eDr. Britigan, et al; Advances in Experimental Medicine and Biology\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Sequence","offers":[{"title":"Default Title","offer_id":43007194497195,"sku":"699100-DiscoSupplier","price":41.97,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0621\/4126\/8139\/files\/sequence-colostrum-powder-50g.jpg?v=1710970206"}],"url":"https:\/\/www.vitamart.ca\/fr\/collections\/colostrum.oembed","provider":"Vitamart.ca","version":"1.0","type":"link"}