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Product Rating

Overall: 9.5/10
Effectiveness: 9.7/10
Value: 8/10
#Reviews: 3

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AOR SAMe, 400mg

Vitamart Price:  $58.45
Temporarily Out of Stock


AOR SAMe 400 Details

  • Supports depressed mood
  • Relieves symptoms of osteoarthritis
  • Supports normal liver function
  • Supports methylation

SAMe 400 is s-adenosyl-L-methionine (SAMe), a key biological factor that drives a wide variety of essential biochemical reactions, including the methylation of DNA, catecholamine neurotransmitters (brain messenger-molecules), phospholipids, hormones, and chondrocytes (cartilage-forming cells). Research suggests SAMe's ability to support healthy mood function and to relieve symptoms and reduce functional impairment in osteoarthritis. SAMe 400 provides a full 400 mg of true SAMe ion per enterically coated tablet, with a minimum of 70% biologically active (S),S-diastereoisomer.

S-Adenosyl-L-Methionine (SAMe) is a natural compound and methyl group donor that supports the methylation cycle, a process which is essential for many aspects of health. Methylation is fundamental for ridding the body of certain toxins, and certain people, such as those with chronic liver disorders, cannot produce adequate levels of SAMe. 
SAMe’s effectiveness to support a balanced mood is demonstrated by many clinical studies. SAMe is in fact so effective for boosting a low mood that it is legally registered as a prescription drug in several European countries for mood balance.  One study showed that SAMe was as effective as a common prescription medication for mood. It is thought that SAMe works by help boosting serotonin, dopamine and melatonin levels in the brain, low levels of which are commonly associated with mood imbalances such as anxiety and depression. SAMe has also been found to support joint health in osteoarthritis patients as effectively as a popular anti-inflammatory drug by reducing inflammation and protecting joint tissue from degradation. 
AOR introduced the first SAMe supplement to Canada in 2000. SAMe can provide mood support, benefit those suffering from osteoarthritis, and is essential for those with liver disorders to maintain good health. AOR’s SAMe 400 provides an effective dosage and a stable form of this valuable compound in an enteric coated tablet for maximum effectiveness.

AOR SAMe Reviews*

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Product rating*

Product Rating: 9.5/10

Customer Reviews*

  • 10/10  Excellent

    By SHANNON on Monday, October 5, 2020 12:35 AM

    Effectiveness: 10/10

    (+) Good Value,Reduced My Pain

    How did you use it?:Everyday

    "Would not be without it."

    Would you buy this product again? Yes
    Verified by Vitamart Purchaser

    Was this review helpful?  Yes   No  

  • 9.8/10  AOR SAMe - no more antidepressants

    By Andrea on Tuesday, May 14, 2019 11:01 PM

    Effectiveness: 10/10

    (+) Eliminated the need for Rx antidepressants

    How did you use it?:Before Bed,Every Morning

    "After 19 years of being on citalopram (Celexa) I went weaned off in June 2018. By late winter I was noticing some mood imbalances and researched what supplements were recommended for depression. Within 24 hours of taking my first dose of SAMe I noticed real improvement and haven't looked back. I began with 800 mg and am now at the minimum dose of 400 mg. It's not an inexpensive alternative but I feel fantastic."

    Would you buy this product again? Yes
    Verified by Vitamart Purchaser

    Was this review helpful?  Yes   No  

  • 8.7/10  Great Product

    By MrsC on Monday, January 15, 2018 12:06 AM

    Effectiveness: 9/10

    (+) Reduced My Pain

    How did you use it?:Everyday

    "I take one pill every morning and 1 capsule of NEM every night and it virtually eliminated my arthritis aches and pains. On a scale of 1-10 my pain level is a 1.
    I will never be without this product. The usual arthritis supplements (glucosamine, MSM, chondroitin) do not work for me. This does. Product is a bit pricey though."

    Would you buy this product again? Yes
    Verified by Vitamart Purchaser

    Was this review helpful?  Yes   No  

*Review Disclaimer: Not everyone has these results. Product experiences vary from person to person. Please use these reviews for information only as they have not been reviewed by a medical professional. Do not substitute the informatioin in the reviews for advice from your physician or other health care professional or any information contained on or in any product label or packaging.

Suggested Use

Take 2 or 3 AOR SAMe 400 tablets daily on an empty stomach, or as directed by a qualified health care practitioner. Use for a minimum of 4 weeks to see beneficial effects for osteoarthritic pain, and a minimum of 2 weeks for mood support.

Nutrition Facts
Serving Size: 1 Tablet
Servings per Container: 30
Amount Per Serving
S-Adenosyl-L-Methioinine (SAMe) (Disulfate P-Toluensulfonate) 770 mg
Providing ionic SAMe (Min. 70% (S),S-diastereoisomer) 400 mg
* Percent daily values are based on a 2000 calorie diet
  † Daily Value not established
Note: Serving Sizes are rounded to the nearest whole serving

Additional Ingredients: Silicon dioxide, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, ascorbic acid, citric acid (anhydrous), stearic acid, methacrylic acid co-polymer dispersion NF, triethyl citrate, titanium dioxide, riboflavin, mannitol.

Allergy Information: n/a

Warning: Do not take at night since this product may cause anxiety, restlessness and insomnia. Consult with a health care practitioner prior to use if you suffer from depression or are taking medications which may influence serotonin levels (e.g. antidepressants). Pregnancy/Nursing: Consult a health care practitioner

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